@article{oai:soar-ir.repo.nii.ac.jp:00020088,
 author = {Misaka, T and Suzuki, S and Sakamoto, N and Yamaki, T and Sugimoto, K and Kunii, H and Nakazato, K and Saitoh, S and Sawamura, T and Ishibashi, T and Takeishi, Y},
 journal = {BIOMED RESEARCH INTERNATIONAL},
 month = {May},
 note = {Background. Soluble lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) level is a novel biomarker for diagnosis of acute coronary syndrome (ACS); however, this level in the coronary circulation has yet to be examined. Methods. Twenty-seven consecutive patients with ACS and 40 patients with effort angina pectoris (EAP) undergoing percutaneous coronary intervention (PCI) had levels of soluble LOX-1 and LOX-1 index measured in paired blood samples from aorta (Ao) and coronary sinus (CS) just prior to the PCI. Results.We found positive correlations between soluble LOX-1 levels in the Ao and CS in both ACS and EAP patients (????P < 0.01, for both). The soluble LOX-1 levels in the Ao and CS were higher in ACS than in EAP patients (????P < 0.01, for both).The levels of soluble LOX-1 and LOX-1 index of the CS were significantly greater than those of the Ao in both ACS and EAP patients (????P < 0.01, for both). Receiver operating characteristic curves for ACS detection demonstrated high sensitivity and specificity for the solubleLOX-1 andLOX-1 indexwith no differences between theAo andCS. Conclusions.Thepresent study showed that circulating soluble LOX-1 originates from coronary circulation and soluble LOX-1 and LOX-1 index are useful biomarkers for ACS., Article, BIOMED RESEARCH INTERNATIONAL.2014:649185(2014)},
 title = {Significance of Soluble Lectin-Like Oxidized LDL Receptor-1 Levels in Systemic and Coronary Circulation in Acute Coronary Syndrome},
 volume = {2014},
 year = {2014}
}