{"created":"2021-03-01T06:23:12.367146+00:00","id":20097,"links":{},"metadata":{"_buckets":{"deposit":"54b62e44-b898-4911-a3b9-ca3f0271d30b"},"_deposit":{"id":"20097","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20097"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00020097","sets":["461:462"]},"author_link":["106308","106309","106310","106311","106312","106313","106314","106315","106316","106317","106318","106319","106320","106321"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"379","bibliographicPageStart":"370","bibliographicVolumeNumber":"93","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF NEUROSCIENCE RESEARCH"}]}]},"item_6_description_19":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文のみを公開。","subitem_description_type":"Other"}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The loss of homeostasis of essential metals is associated with various diseases, including neurodegenerative diseases. Previous studies have shown that the levels of zinc (Zn) are significantly higher in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis (ALS). Zn transporters and metallothioneins tightly control intracellular and extracellular Zn levels. This study investigated the protein levels of ZnT, a Zn transporter family, in ALS patients and model mice. The mRNA expression of ZnT1, −3, −4, −5, −6, −7, and −10 was assessed in the spinal cords of human control subjects. ZnT3 and ZnT6 protein levels were significantly diminished in the spinal cords of sporadic ALS patients compared with controls. Furthermore, immunohistochemical staining demonstrated decreased ZnT3 and ZnT6 immunoreactivity in the ventral horn of the spinal cords in ALS patients. Moreover, immunohistochemical analysis revealed that all ZnTs expressed in the spinal cords were localized in a distinct subset of motor neurons. In addition, ZnT3 and ZnT6 protein levels were not altered in SOD1 (G93A) mutant transgenic mice before or after the onset of ALS symptoms compared with controls. These results suggest that ZnT3 and ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients; however, this did not occur merely via loss of motor neurons. © 2014 Wiley Periodicals, Inc.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Oyanagi, Kiyomitsu","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jhTCPpym.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000346475600016"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY-BLACKWELL"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"25284286"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/25284286","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1002/jnr.23491"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1002/jnr.23491","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: [JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014)], which has been published in final form at [https://doi.org/10.1002/jnr.23491]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1097-4547","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11623725","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kaneko, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noguchi, Takao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106309","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikegami, Saori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Takeyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106311","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakita, Akiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyoshima, Yasuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kambe, Taiho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Mitsunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inden, Masatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oyanagi, Kiyomitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inuzuka, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hozumi, Isao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106321","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-09-13"}],"displaytype":"detail","filename":"25640028_01.pdf","filesize":[{"value":"728.1 kB"}],"format":"application/pdf","licensefree":"This is the peer reviewed version of the following article: [JOURNAL OF NEUROSCIENCE RESEARCH.93(2):370-379(2014)], which has been published in final form at [https://doi.org/10.1002/jnr.23491]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25640028_01.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/20097/files/25640028_01.pdf"},"version_id":"ea8edb44-49bb-470a-b5e9-b39f2827106b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"biometal","subitem_subject_scheme":"Other"},{"subitem_subject":"ER stress","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-09-13"},"publish_date":"2018-09-13","publish_status":"0","recid":"20097","relation_version_is_last":true,"title":["Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:27:15.896591+00:00"}