{"created":"2021-03-01T06:23:20.865553+00:00","id":20236,"links":{},"metadata":{"_buckets":{"deposit":"fa6b5a18-c0cd-499d-a114-4b37b370eed3"},"_deposit":{"id":"20236","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20236"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00020236","sets":["461:462"]},"author_link":["106741","106742","106743","106744"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"3073504","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF IMMUNOLOGY RESEARCH"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades. Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens. In this review, we describe the influence of HLA alleles and other gene polymorphisms on PBC along with the results of genome-wide association studies (GWAS) on this disease.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JOURNAL OF IMMUNOLOGY RESEARCH. :3073504(2017)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Umemura, Takeji","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394871600001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"HINDAWI LTD"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1155/2017/3073504"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1155/2017/3073504","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2017 Satoru Joshita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2314-8861","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Joshita, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106741","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umemura, Takeji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106742","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"106744","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-31"}],"displaytype":"detail","filename":"3073504.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensefree":"© 2017 Satoru Joshita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"3073504.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/20236/files/3073504.pdf"},"version_id":"403b463e-87cf-4305-943d-6993519a115c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-10-31"},"publish_date":"2018-10-31","publish_status":"0","recid":"20236","relation_version_is_last":true,"title":["Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:40:39.114749+00:00"}