@article{oai:soar-ir.repo.nii.ac.jp:00020249,
 author = {Nakao, Kazumasa and Osawa, Kenji and Yasoda, Akihiro and Yamanaka, Shigeki and Fujii, Toshihito and Kondo, Eri and Koyama, Noriaki and Kanamoto, Naotetsu and Miura, Masako and Kuwahara, Koichiro and Akiyama, Haruhiko and Bessho, Kazuhisa and Nakao, Kazuwa},
 journal = {SCIENTIFIC REPORTS},
 month = {May},
 note = {Recent studies revealed C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of endochondral bone growth. As they exist ubiquitously in body, we investigated the physiological role of the local CNP/GC-B in the growth plate on bone growth using cartilage-specific knockout mice. Bones were severely shorter in cartilage-specific CNP or GC-B knockout mice and the extent was almost the same as that in respective systemic knockout mice. Cartilage-specific GC-B knockout mice were shorter than cartilage-specific CNP knockout mice. Hypertrophic chondrocyte layer of the growth plate was drastically reduced and proliferative chondrocyte layer, along with the proliferation of chondrocytes there, was moderately reduced in either cartilage-specific knockout mice. The survival rate of cartilage-specific CNP knockout mice was comparable to that of systemic CNP knockout mice. The local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth and might further affect mortality via unknown mechanisms., Article, SCIENTIFIC REPORTS. 5: 10554(2015)},
 title = {The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth},
 volume = {5},
 year = {2015}
}