{"created":"2021-03-01T06:23:48.796067+00:00","id":20697,"links":{},"metadata":{"_buckets":{"deposit":"ac49a98f-ff70-40ff-9373-d2f9bb6931a8"},"_deposit":{"id":"20697","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20697"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00020697","sets":["1016:1017"]},"author_link":["107977","107978","107979","107980"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"122","bibliographicPageStart":"115","bibliographicVolumeNumber":"91","bibliographic_titles":[{"bibliographic_title":"DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY"}]}]},"item_6_description_19":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Epub 2018 Oct 30","subitem_description_type":"Other"}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Toll-like receptors (TLRs) are a group of sensory receptors which are capable of recognizing a microbial invasion and activating innate immune system responses, including inflammatory responses, in both immune and non immune cells. However, TLR functions in chick myoblasts, which are myogenic precursor cells contributing to skeletal muscle development and growth, have not been studied. Here, we report the expression patterns of TLR genes as well as TLR ligand-dependent transcriptions of interleukin (IL) genes in primary-cultured chick myoblasts. Almost TLR genes were expressed both in layer and broiler myoblasts but TLR1A was detected only in embryonic layer chick myoblasts. Chick TLR1/2 ligands, Pam(3)CSK(4) and FSL-1, induced inflammatory ILs in both layer and broiler myoblasts but a TLR4 ligand, lipopolysaccharide, scarcely promoted. This is the first report on TLR ligand-dependent inflammatory responses in chick myoblasts, which may provide useful information to chicken breeding and meat production industries.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 91:115-122 (2019)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Ono, Tamao","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WFfCPpkh.html"},{"subitem_link_text":"Kagami, Hiroshi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OeyUPUkh.html"},{"subitem_link_text":"Takaya, Tomohide","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000451492900013"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER SCI LTD"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"30389519"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/30389519/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.dci.2018.10.013"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.dci.2018.10.013","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ "}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0145-305X","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00627870","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nihashi, Yuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ono, Tamao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kagami, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaya, Tomohide"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-30"}],"displaytype":"detail","filename":"2019_DevCompImmunol_Nihashi_SOAR.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"2019_DevCompImmunol_Nihashi_SOAR.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/20697/files/2019_DevCompImmunol_Nihashi_SOAR.pdf"},"version_id":"a0fa7800-5ec3-415c-a7fd-e753bcb4dbe9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Inflammatory response","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin","subitem_subject_scheme":"Other"},{"subitem_subject":"Skeletal muscle myoblast","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-like receptor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Toll -like receptor ligand-dependent inflammatory responses in chick skeletal muscle myoblasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Toll -like receptor ligand-dependent inflammatory responses in chick skeletal muscle myoblasts","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"20697","relation_version_is_last":true,"title":["Toll -like receptor ligand-dependent inflammatory responses in chick skeletal muscle myoblasts"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:30:23.948202+00:00"}