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Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T-cell activation markers\uff08\u9aa8\u8089\u816b\u306e\u81e8\u5e8a\u6210\u7e3e\u304a\u3088\u3073programmed death-ligand1, T\u7d30\u80de\u6d3b\u6027\u30de\u30fc\u30ab\u30fc\u3068\u306e\u76f8\u95a2\uff09. \u4fe1\u5dde\u5927\u5b66, 2019, \u535a\u58eb\u8ad6\u6587.", "subitem_description_type": "Other"}]}, "item_14_dissertation_number_7": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13601\u7532\u7b2c1166\u53f7"}]}, "item_14_link_74": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000463763900005"}]}, "item_14_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u4fe1\u5dde\u5927\u5b66"}]}, "item_14_relation_54": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "31040694"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=31040694", "subitem_relation_type_select": "PMID"}}]}, "item_14_relation_55": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.2147/OTT.S198421"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.2147/OTT.S198421", "subitem_relation_type_select": "DOI"}}]}, "item_14_rights_69": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 2019 Yoshida et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution \u2013 Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)."}]}, "item_14_select_71": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_14_text_11": {"attribute_name": "\u5b66\u4f4d\u306e\u533a\u5206", "attribute_value_mlt": [{"subitem_text_value": "Doctoral"}]}, "item_14_text_12": {"attribute_name": "\u5b66\u4f4d\u306e\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "\u533b\u5b66"}]}, "item_14_text_13": {"attribute_name": "\u5b66\u4f4d\u306e\u5831\u544a\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u7532\u7b2c1166\u53f7"}]}, "item_14_text_76": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "anti-PD-1 antibody; perforin; granzyme B; IFN gamma; osteosarcoma; clinical outcome"}]}, "item_14_text_77": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "HIGH-GRADE OSTEOSARCOMA; PD-L1 EXPRESSION; PROGNOSTIC-FACTORS; CANCER; BONE"}]}, "item_14_textarea_75": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Purpose: Although both anti-PD-1 antibody and treatments using anti-PD-L1 antibody are currently in clinical use, their therapeutic effects vary according to cancer type. One of the factors accounting for this variability is the expression level of the immune checkpoint molecule that differs between cancer types; thus, it is important to clarify the relationship between clinical outcomes and immune checkpoint molecules for all types of human cancer. The purpose of this study is to evaluate the clinical outcome of osteosarcoma in relation to PD-L1, PRF, GZMB, and IFN gamma expression. Methods: Using 19 clinical specimens of osteosarcoma, we examined the expression of PD-L1, PRF, GZMB, and IFN. in relation to their clinical outcomes. Results: PD-L1 expression correlated with early metastatic formation in clinical specimens of osteosarcoma, and the group with highly expressed functional markers for T cells such as PRF and GZMB resulted in a long overall survival time. Conclusion: This is the first study to elucidate the clinical outcomes of osteosarcoma in relation to PD-L1, PRF, GZMB, and IFN gamma expression. This study provides valuable information regarding the clinical indication and prediction of effect for anti-PD-1 antibody in osteosarcoma."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5409\u7530, \u548c\u85ab"}], "nameIdentifiers": [{"nameIdentifier": "108085", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "15MH042E_yoshi.pdf", "filesize": [{"value": "122.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 122800.0, "url": {"label": "\u5185\u5bb9\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20749/files/15MH042E_yoshi.pdf"}, "version_id": "dd3c6da8-ebb5-4b04-9d1f-8868dd6974c4"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "15MH042E_shinsa.pdf", "filesize": [{"value": "111.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 111400.0, "url": {"label": "\u5be9\u67fb\u7d50\u679c\u306e\u8981\u65e8", "url": "https://soar-ir.repo.nii.ac.jp/record/20749/files/15MH042E_shinsa.pdf"}, "version_id": "7c0d97e2-4088-47b4-bf3e-a99e86ab0f20"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-06-13"}], "displaytype": "detail", "download_preview_message": "", "file_order": 2, "filename": "15MH042E_ronbun.pdf", "filesize": [{"value": "384.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_9", "mimetype": "application/pdf", "size": 384700.0, "url": {"label": "\u535a\u58eb\u8ad6\u6587\u306e\u5168\u6587", "url": "https://soar-ir.repo.nii.ac.jp/record/20749/files/15MH042E_ronbun.pdf"}, "version_id": "e837ba8f-463f-4869-ad6a-2cc823220ad6"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T-cell activation markers\uff08\u9aa8\u8089\u816b\u306e\u81e8\u5e8a\u6210\u7e3e\u304a\u3088\u3073programmed death-ligand1, T\u7d30\u80de\u6d3b\u6027\u30de\u30fc\u30ab\u30fc\u3068\u306e\u76f8\u95a2\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T-cell activation markers\uff08\u9aa8\u8089\u816b\u306e\u81e8\u5e8a\u6210\u7e3e\u304a\u3088\u3073programmed death-ligand1, T\u7d30\u80de\u6d3b\u6027\u30de\u30fc\u30ab\u30fc\u3068\u306e\u76f8\u95a2\uff09"}]}, "item_type_id": "14", "owner": "1", "path": ["461/848/849"], "permalink_uri": "http://hdl.handle.net/10091/00021507", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2019-06-14"}, "publish_date": "2019-06-14", "publish_status": "0", "recid": "20749", "relation": {}, "relation_version_is_last": true, "title": ["Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T-cell activation markers\uff08\u9aa8\u8089\u816b\u306e\u81e8\u5e8a\u6210\u7e3e\u304a\u3088\u3073programmed death-ligand1, T\u7d30\u80de\u6d3b\u6027\u30de\u30fc\u30ab\u30fc\u3068\u306e\u76f8\u95a2\uff09"], "weko_shared_id": 3}