{"created":"2021-03-01T06:23:56.321513+00:00","id":20817,"links":{},"metadata":{"_buckets":{"deposit":"425fe058-ac8f-4b0f-9d1b-6c26be57f13a"},"_deposit":{"id":"20817","owners":[],"pid":{"revision_id":0,"type":"depid","value":"20817"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00020817","sets":["1016:1017"]},"author_link":["108183","108184","108185","108186","108187","108188","108189"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"106","bibliographicPageStart":"98","bibliographicVolumeNumber":"646","bibliographic_titles":[{"bibliographic_title":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adipose tissues in obese individuals are characterized by a state of chronic low-grade inflammation. Pre-adipocytes and adipocytes in this state secrete pro-inflammatory adipokines, such as interleukin 6 (IL-6), which induce insulin resistance and hyperglycemia. Theophylline (1,3-dimethylxanthine) exerts anti-inflammatory effects, but its effects on pro-inflammatory adipokine secretion by pre-adipocytes and adipocytes have not been examined. In this study, we found that theophylline decreased IL-6 secretion by 3T3-L1 pre-adipocytes and mouse-derived primary pre-adipocytes. The synthetic glucocorticoid dexamethasone (DEX) induced IL-6 expression in 3T3-L1 pre-adipocytes, and this effect was suppressed by theophylline at the mRNA level. Knockdown of CCAAT/enhancer binding protein (C/EBP) δ inhibited DEX-induced IL-6 expression, and theophylline suppressed C/EBPδ expression. Furthermore, theophylline suppressed transcriptional activity of the glucocorticoid receptor (GR) through suppression of nuclear localization of GR. In vivo, glucocorticoid corticosterone treatment (100 μg/mL) increased fasting blood glucose and plasma IL-6 levels in C57BL/6 N mice. Theophylline administration (0.1% diet) reduced corticosterone-increased fasting blood glucose, plasma IL-6 levels, and Il6 gene expression in adipose tissues. These results show that theophylline administration attenuated glucocorticoid-induced hyperglycemia and IL-6 production by inhibiting GR activity. The present findings indicate the potential of theophylline as a candidate therapeutic agent to treat insulin resistance and hyperglycemia.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.646:98-106(2018)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Mitani, Takakazu","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html"},{"subitem_link_text":"Takaya, Tomohide","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html"},{"subitem_link_text":"Katayama, Shigeru","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.HFkaPUkh.html"},{"subitem_link_text":"Nakamura, Soichiro","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OpyhuNDp.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000431838200013"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER SCIENCE INC"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"29625124"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/29625124/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.abb.2018.04.001"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.abb.2018.04.001","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0003-9861","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00547159","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitani, Takakazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaya, Tomohide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Katayama, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaji, Ryoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Soichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ashida, Hitoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-24"}],"displaytype":"detail","filename":"2018_ArchBiochemBiophys_Mitani_SOAR.pdf","filesize":[{"value":"852.2 kB"}],"format":"application/pdf","licensefree":"© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018_ArchBiochemBiophys_Mitani_SOAR.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/20817/files/2018_ArchBiochemBiophys_Mitani_SOAR.pdf"},"version_id":"ff069a10-6d69-4ca1-99c9-2d08e5c3c836"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adipocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"CCAAT-Enhancer-binding proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucocorticoid receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin-6","subitem_subject_scheme":"Other"},{"subitem_subject":"Theophylline","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-24"},"publish_date":"2019-07-24","publish_status":"0","recid":"20817","relation_version_is_last":true,"title":["Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:18:09.027382+00:00"}