@article{oai:soar-ir.repo.nii.ac.jp:00020856,
 author = {Imamura, Tetsuya and Ishizuka, Osamu and Ogawa, Teruyuki and Yamagishi, Takahiro and Yokoyama, Hitoshi and Minagawa, Tomonori and Nakazawa, Masaki and Nishizawa, Osamu},
 issue = {1},
 journal = {LUTS-LOWER URINARY TRACT SYMPTOMS},
 month = {Mar},
 note = {ObjectiveTo investigate pathways involving beta-3 adrenergic receptors (ARs) in detrusor overactivity induced by cold stress, we determined if the beta-3 AR agonist CL316243 could modulate the cold stress-induced detrusor overactivity in normal rats. MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results<p id="luts12050-para-0003">At RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of CL316243 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1mg/kg)-treated rats. Conclusion<p id="luts12050-para-0004">A high dose of the beta-3 agonist CL316243 could modulate cold stress-induced detrusor overactivity. Therefore, one of the mechanisms in cold stress-induced detrusor overactivity includes a pathway involving beta-3 ARs., Article, LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2014)},
 pages = {50--55},
 title = {Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-Induced Detrusor Overactivity in Conscious Rats},
 volume = {7},
 year = {2014}
}