At RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of CL316243 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1mg/kg)-treated rats. Conclusion
A high dose of the beta-3 agonist CL316243 could modulate cold stress-induced detrusor overactivity. Therefore, one of the mechanisms in cold stress-induced detrusor overactivity includes a pathway involving beta-3 ARs.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2014)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Imamura, Tetsuya","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html"},{"subitem_link_text":"Ishizuka, Osamu","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html"},{"subitem_link_text":"Ogawa, Teruyuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yhTUgpkh.html"},{"subitem_link_text":"Minagawa, Tomonori","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jCfagUkh.html"},{"subitem_link_text":"Nishizawa, Osamu","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000348738700009"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY-BLACKWELL"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"26663652"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/26663652","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1111/luts.12050"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/luts.12050","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2015), which has been published in final form at [https://doi.org/10.1111/luts.12050]. 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