{"created":"2021-03-01T06:24:09.192001+00:00","id":21027,"links":{},"metadata":{"_buckets":{"deposit":"d5082de8-e837-49a9-9f09-586f68c418f6"},"_deposit":{"id":"21027","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21027"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00021027","sets":["1016:1017"]},"author_link":["108776","108777","108778","108779","108780"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"75","bibliographicPageStart":"63","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY"}]}]},"item_6_description_19":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Published online: 29 Aug 2019","subitem_description_type":"Other"}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cells via inducing cell cycle arrest. However, it has not been investigated whether berberine and its analogs inhibit the growth of rhabdomyosarcoma (RMS), which is the most frequent soft tissue tumor in children. The present study examined the anti-tumor effects of berberine and palmatine on expansions of three human embryonal RMS cell lines; ERMS1, KYM1, and RD. Intracellular incorporation of berberine was relatively higher than that of palmatine in every RMS cell line. Berberine significantly inhibited the cell cycle of all RMS cells at G(1) phase. On the other hand, palmatine only suppressed the growth of RD cells. Both of berberine and palmatine strongly inhibited the growth of tumorsphere of RD cells in three-dimensional culture. These results indicate that berberine derivatives have the potential of anti-tumor drugs for RMS therapy.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 84(1):63-75 (2020)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Umezawa, Koji","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yVcFPhkh.html"},{"subitem_link_text":"Takaya, Tomohide","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000484642100001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"TAYLOR & FRANCIS LTD"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"31462179"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/31462179/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1080/09168451.2019.1659714"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/09168451.2019.1659714","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 2020, available online: https://doi.org/10.1080/09168451.2019.1659714."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-8451","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10824164","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinji, Sayaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Shunichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nihashi, Yuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umezawa, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaya, Tomohide"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-29"}],"displaytype":"detail","filename":"2020_BBB_Shinji_SOAR.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensefree":"This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 2020, available online: https://doi.org/10.1080/09168451.2019.1659714.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2020_BBB_Shinji_SOAR.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/21027/files/2020_BBB_Shinji_SOAR.pdf"},"version_id":"14e10405-f1c3-4f9c-b980-eeef9753e0cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Berberine","subitem_subject_scheme":"Other"},{"subitem_subject":"palmatine","subitem_subject_scheme":"Other"},{"subitem_subject":"rhabdomyosarcoma","subitem_subject_scheme":"Other"},{"subitem_subject":"three-dimensional culture","subitem_subject_scheme":"Other"},{"subitem_subject":"tumorsphere","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1017"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-12-05"},"publish_date":"2019-12-05","publish_status":"0","recid":"21027","relation_version_is_last":true,"title":["Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:18:34.429685+00:00"}