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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin

http://hdl.handle.net/10091/00022442
8296e324-e026-453b-9e4f-2a58420f7815
名前 / ファイル ライセンス アクション
2021_FrontCellDevBiol_Shinji.pdf 2021_FrontCellDevBiol_Shinji.pdf (3.3 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-01-12
タイトル
言語 en
タイトル Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin
言語
言語 eng
キーワード
主題Scheme Other
主題 oligodeoxynucleotide (ODN)
キーワード
主題Scheme Other
主題 berberine (CID: 12457)
キーワード
主題Scheme Other
主題 nucleolin (NCL)
キーワード
主題Scheme Other
主題 skeletal muscle myoblast
キーワード
主題Scheme Other
主題 myogenic differentiation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shinji, Sayaka

× Shinji, Sayaka

WEKO 110007

Shinji, Sayaka

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Umezawa, Koji

× Umezawa, Koji

WEKO 110008

Umezawa, Koji

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Nihashi, Yuma

× Nihashi, Yuma

WEKO 110009

Nihashi, Yuma

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Nakamura, Shunichi

× Nakamura, Shunichi

WEKO 110010

Nakamura, Shunichi

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Shimosato, Takeshi

× Shimosato, Takeshi

WEKO 110011

Shimosato, Takeshi

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Takaya, Tomohide

× Takaya, Tomohide

WEKO 110012

Takaya, Tomohide

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信州大学研究者総覧へのリンク
氏名 Umezawa, Koji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yVcFPhkh.html
信州大学研究者総覧へのリンク
氏名 Shimosato, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
信州大学研究者総覧へのリンク
氏名 Takaya, Tomohide
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yUcePUkh.html
出版者
出版者 FRONTIERS MEDIA SA
引用
内容記述タイプ Other
内容記述 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 8:616706 (2021)
書誌情報 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

巻 8, p. 616706, 発行日 2021-01-11
抄録
内容記述タイプ Abstract
内容記述 Herein we report that the 18-base telomeric oligodeoxynucleotides (ODNs) designed from the Lactobacillus rhamnosus GG genome promote differentiation of skeletal muscle myoblasts which are myogenic precursor cells. We termed these myogenetic ODNs (myoDNs). The activity of one of the myoDNs, iSN04, was independent of Toll-like receptors, but dependent on its conformational state. Molecular simulation and iSN04 mutants revealed stacking of the 13–15th guanines as a core structure for iSN04. The alkaloid berberine bound to the guanine stack and enhanced iSN04 activity, probably by stabilizing and optimizing iSN04 conformation. We further identified nucleolin as an iSN04-binding protein. Results showed that iSN04 antagonizes nucleolin, increases the levels of p53 protein translationally suppressed by nucleolin, and eventually induces myotube formation by modulating the expression of genes involved in myogenic differentiation and cell cycle arrest. This study shows that bacterial-derived myoDNs serve as aptamers and are potential nucleic acid drugs directly targeting myoblasts.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 2296-634X
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3389/fcell.2020.616706
関連名称
関連名称 10.3389/fcell.2020.616706
権利
権利情報 Copyright © 2021 Shinji, Umezawa, Nihashi, Nakamura, Shimosato and Takaya.This is an open-access article distributed under the terms of the Creative CommonsAttribution License (CC BY). The use, distribution or reproduction in other forumsis permitted, provided the original author(s) and the copyright owner(s) are creditedand that the original publication in this journal is cited, in accordance with acceptedacademic practice. No use, distribution or reproduction is permitted which does notcomply with these terms.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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