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Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPAR gamma activation in human umbilical vein endothelial cells
http://hdl.handle.net/10091/00022482
http://hdl.handle.net/10091/00022482f89142bd-06bd-466f-912b-d41142b5c302
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPAR gamma activation in human umbilical vein endothelial cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AGP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PPAR gamma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CCL-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ROS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peroxidation | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Yamagishi, Shuhei× Matsuda, Yoshikazu× Haniu, Hisao |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Haniu, Hisao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
出版者 | ||||||
出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BIOMEDICINE & PHARMACOTHERAPY. 106:686-691 (2018) | |||||
書誌情報 |
BIOMEDICINE & PHARMACOTHERAPY 巻 106, p. 686-691, 発行日 2018-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma). On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPAR gamma. However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis. We showed that AGP enhances CCL-2 mRNA expression and secretion in a dose-dependent manner. Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPAR gamma antagonist. These results suggest that an imbalance of the PPAR gamma agonist-antagonist equilibrium is involved in changes in cellular functions, including ROS generation and lipid peroxidation. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0753-3322 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10506249 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/29990859 | |||||
関連名称 | 29990859 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.biopha.2018.07.012 | |||||
関連名称 | 10.1016/j.biopha.2018.07.012 | |||||
権利 | ||||||
権利情報 | ©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000442600300082 |