{"_buckets": {"deposit": "7169913a-43c4-4d56-bcd5-aa8258960525"}, "_deposit": {"id": "21725", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21725"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00021725"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-10", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "691", "bibliographicPageStart": "686", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "BIOMEDICINE \u0026 PHARMACOTHERAPY"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma). On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPAR gamma. However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis. We showed that AGP enhances CCL-2 mRNA expression and secretion in a dose-dependent manner. Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPAR gamma antagonist. 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On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPAR gamma. However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis. We showed that AGP enhances CCL-2 mRNA expression and secretion in a dose-dependent manner. Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPAR gamma antagonist. 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