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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPAR gamma activation in human umbilical vein endothelial cells

http://hdl.handle.net/10091/00022482
f89142bd-06bd-466f-912b-d41142b5c302
名前 / ファイル ライセンス アクション
BIOMED_PHARMACOTHER-106-686.pdf BIOMED_PHARMACOTHER-106-686.pdf (3.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-04
タイトル
言語 en
タイトル Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPAR gamma activation in human umbilical vein endothelial cells
言語
言語 eng
キーワード
主題Scheme Other
主題 AGP
キーワード
主題Scheme Other
主題 PPAR gamma
キーワード
主題Scheme Other
主題 CCL-2
キーワード
主題Scheme Other
主題 ROS
キーワード
主題Scheme Other
主題 Peroxidation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 110112

en Tsukahara, Tamotsu

Search repository
Yamagishi, Shuhei

× Yamagishi, Shuhei

WEKO 110113

en Yamagishi, Shuhei

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 110114

en Matsuda, Yoshikazu

Search repository
Haniu, Hisao

× Haniu, Hisao

WEKO 110115

en Haniu, Hisao

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
引用
内容記述タイプ Other
内容記述 BIOMEDICINE & PHARMACOTHERAPY. 106:686-691 (2018)
書誌情報 BIOMEDICINE & PHARMACOTHERAPY

巻 106, p. 686-691, 発行日 2018-10
抄録
内容記述タイプ Abstract
内容記述 We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPAR gamma). On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negatively regulate PPAR gamma. However, in this study, cPA had no effect on the expression and secretion of C-C motif chemokine 2 (CCL-2), a chemokine that is also linked to inflammatory responses and atherosclerosis. We showed that AGP enhances CCL-2 mRNA expression and secretion in a dose-dependent manner. Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPAR gamma antagonist. These results suggest that an imbalance of the PPAR gamma agonist-antagonist equilibrium is involved in changes in cellular functions, including ROS generation and lipid peroxidation.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0753-3322
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10506249
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/29990859
関連名称
関連名称 29990859
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.biopha.2018.07.012
関連名称
関連名称 10.1016/j.biopha.2018.07.012
権利
権利情報 ©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000442600300082
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