{"created":"2021-03-01T06:24:52.892131+00:00","id":21726,"links":{},"metadata":{"_buckets":{"deposit":"3abd6e2a-8fa1-4295-9b19-b61ffc7ecf05"},"_deposit":{"id":"21726","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21726"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00021726","sets":["461:462"]},"author_link":["110116","110117","110118","110119"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"113","bibliographicPageStart":"100","bibliographicVolumeNumber":"473","bibliographic_titles":[{"bibliographic_title":"MOLECULAR AND CELLULAR ENDOCRINOLOGY"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alkyl-glycerophosphate (AGP) accumulates in atherogenic oxidized-LDL and human atherosclerotic plaques and is a potent agonist of peroxisome-proliferator-activated receptor-gamma (PPAR gamma). Recent studies suggest a potential regulatory role for PPAR gamma in endothelial nitric oxide synthase (eNOS) expression/activation and nitrogen oxide (NO) generation in the vascular endothelium. Importantly, eNOS-induced NO and advanced glycation end-products (AGEs) are involved in blood-vessel damage, and diabetic patients exhibit high serum NO and AGE levels; however, the effect of AGP on NO- and AGE-mediated endothelium dysfunction remains unknown. Investigation of the AGP-specific effects on NO- and AGE-mediated dysfunction and the underlying molecular mechanisms revealed that AGP upregulated eNOS expression and NO production, and that eNOS silencing and gamma antagonism inhibited AGP-mediated eNOS upregulation and NO production. Moreover, AGP-PPAR gamma-axis-mediated NO production promoted the generation of reactive oxygen species and AGE formation. These results suggested that AGP plays a significant role in the initiation/progression of diabetes-related atherosclerosis through PPAR gamma activation. (C) 2018 Elsevier B.V. All rights reserved.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"MOLECULAR AND CELLULAR ENDOCRINOLOGY. 473:100-113 (2018)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Haniu, Hisao","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000447981900010"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER IRELAND LTD"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"29355589"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/29355589","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.mce.2018.01.008"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.mce.2018.01.008","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0303-7207","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00745811","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsukahara, Ryoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haniu, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuda, Yoshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukahara, Tamotsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"110119","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-04"}],"displaytype":"detail","filename":"MOL_CELL_ENDOCRINOL-473-100.pdf","filesize":[{"value":"11.0 MB"}],"format":"application/pdf","licensefree":"©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MOL_CELL_ENDOCRINOL-473-100.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/21726/files/MOL_CELL_ENDOCRINOL-473-100.pdf"},"version_id":"256354cc-35df-4fdb-aef9-f144111677fd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"eNOS","subitem_subject_scheme":"Other"},{"subitem_subject":"NO","subitem_subject_scheme":"Other"},{"subitem_subject":"Alkyl-glycerophosphate","subitem_subject_scheme":"Other"},{"subitem_subject":"PPAR gamma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The AGP-PPAR gamma axis promotes oxidative stress and diabetic endothelial cell dysfunction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The AGP-PPAR gamma axis promotes oxidative stress and diabetic endothelial cell dysfunction","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-04"},"publish_date":"2021-02-04","publish_status":"0","recid":"21726","relation_version_is_last":true,"title":["The AGP-PPAR gamma axis promotes oxidative stress and diabetic endothelial cell dysfunction"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:19:34.354486+00:00"}