@article{oai:soar-ir.repo.nii.ac.jp:00021727,
 author = {Ishida, Haruka and Haniu, Hisao and Takeuchi, Akari and Ueda, Katsuya and Sano, Mahoko and Tanaka, Manabu and Takizawa, Takashi and Sobajima, Atsushi and Kamanaka, Takayuki and Saito, Naoto},
 issue = {11},
 journal = {MATERIALS},
 month = {Jun},
 note = {We evaluated starfish-derived -tricalcium phosphate (Sf-TCP) obtained by phosphatization of starfish-bone-derived porous calcium carbonate as a potential bone substitute material. The Sf-TCP had a communicating pore structure with a pore size of approximately 10 m. Although the porosity of Sf-TCP was similar to that of Cerasorb M (CM)a commercially available -TCP bone fillerthe specific surface area was roughly three times larger than that of CM. Observation by scanning electron microscopy showed that pores communicated to the inside of the Sf-TCP. Cell growth tests showed that Sf-TCP improved cell proliferation compared with CM. Cells grown on Sf-TCP showed stretched filopodia and adhered; cells migrated both to the surface and into pores. In vivo, vigorous tissue invasion into pores was observed in Sf-TCP, and more fibrous tissue was observed for Sf-TCP than CM. Moreover, capillary formation into pores was observed for Sf-TCP. Thus, Sf-TCP showed excellent biocompatibility in vitro and more vigorous bone formation in vivo, indicating the possible applications of this material as a bone substitute. In addition, our findings suggested that mimicking the microstructure derived from whole organisms may facilitate the development of superior artificial bone., Article, MATERIALS. 12(11):1881 (2019)},
 title = {In Vitro and In Vivo Evaluation of Starfish Bone-Derived -Tricalcium Phosphate as a Bone Substitute Material},
 volume = {12},
 year = {2019}
}