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Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
http://hdl.handle.net/10091/00022490
http://hdl.handle.net/10091/000224908b031b0a-385f-4c5f-b03c-2be0969aafe3
| 名前 / ファイル | ライセンス | アクション |
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s41598-020-60781-1.pdf (2.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-02-04 | |||||
| タイトル | ||||||
| タイトル | Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/s41598-020-60781-1 | |||||
| 関連名称 | 10.1038/s41598-020-60781-1 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Haniu, Hisao× Uemura, Takeshi× Matsuda, Yoshikazu |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Haniu, Hisao | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Uemura, Takeshi | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html | |||||
| 出版者 | ||||||
| 出版者 | NATURE PUBLISHING GROUP | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SCIENTIFIC REPORTS. 10(1):3748 (2020) | |||||
| 書誌情報 |
SCIENTIFIC REPORTS 巻 10, 号 1, p. 3748, 発行日 2020-02-28 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cognitive impairments such as dementia are common in later life, and have been suggested to occur via a range of mechanisms, including oxidative stress, age-related changes to cellular metabolism, and a loss of phospholipids (PLs) from neuronal membranes. PLs are a class of amphipathic lipids that form plasma membrane lipid bilayers, and that occur at high concentrations in neuronal membranes. Our previous study suggested that a porcine liver decomposition product (PLDP) produced via protease treatment may improve cognitive function at older ages, by acting as a rich source of PLs and lysophospholipids (LPLs); however, its specific composition remains unclear. Thus, the present study used a novel liquid chromatography electrospray ionization tandem mass spectrometric (LCMS/MS) protocol to identify the major PLs and LPLs in PLDP. Furthermore, it assessed the effect of identified LPLs on microglial activation in vitro, including cell shape, proliferation, and cell morphology. The results of the conducted analyses showed that PLDP and PLDP-derived LPLs concentrationdependently modulate microglial activation in vitro. In particular, lysophosphatidylcholine (LPC) concentration-dependently promotes cell morphology, likely via effects mediated by the enzyme autotaxin (ATX), since inhibiting ATX also promoted cell morphology, while conversely, increasing ATX production (via treatment with high levels of LPC) abolished this effect. These findings suggest that LPC is likely neuroprotective, and thus, support the importance of further research to assess its use as a therapeutic target to treat age-related cognitive impairments, including dementia. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/32111938 | |||||
| 関連名称 | 32111938 | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000563057000007 | |||||
