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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro

http://hdl.handle.net/10091/00022490
http://hdl.handle.net/10091/00022490
8b031b0a-385f-4c5f-b03c-2be0969aafe3
名前 / ファイル ライセンス アクション
s41598-020-60781-1.pdf s41598-020-60781-1.pdf (2.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-04
タイトル
言語 en
タイトル Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 110188

en Tsukahara, Tamotsu

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Haniu, Hisao

× Haniu, Hisao

WEKO 110189

en Haniu, Hisao

Search repository
Uemura, Takeshi

× Uemura, Takeshi

WEKO 110190

en Uemura, Takeshi

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 110191

en Matsuda, Yoshikazu

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Uemura, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HmANWayV.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS. 10(1):3748 (2020)
書誌情報 SCIENTIFIC REPORTS

巻 10, 号 1, p. 3748, 発行日 2020-02-28
抄録
内容記述タイプ Abstract
内容記述 Cognitive impairments such as dementia are common in later life, and have been suggested to occur via a range of mechanisms, including oxidative stress, age-related changes to cellular metabolism, and a loss of phospholipids (PLs) from neuronal membranes. PLs are a class of amphipathic lipids that form plasma membrane lipid bilayers, and that occur at high concentrations in neuronal membranes. Our previous study suggested that a porcine liver decomposition product (PLDP) produced via protease treatment may improve cognitive function at older ages, by acting as a rich source of PLs and lysophospholipids (LPLs); however, its specific composition remains unclear. Thus, the present study used a novel liquid chromatography electrospray ionization tandem mass spectrometric (LCMS/MS) protocol to identify the major PLs and LPLs in PLDP. Furthermore, it assessed the effect of identified LPLs on microglial activation in vitro, including cell shape, proliferation, and cell morphology. The results of the conducted analyses showed that PLDP and PLDP-derived LPLs concentrationdependently modulate microglial activation in vitro. In particular, lysophosphatidylcholine (LPC) concentration-dependently promotes cell morphology, likely via effects mediated by the enzyme autotaxin (ATX), since inhibiting ATX also promoted cell morphology, while conversely, increasing ATX production (via treatment with high levels of LPC) abolished this effect. These findings suggest that LPC is likely neuroprotective, and thus, support the importance of further research to assess its use as a therapeutic target to treat age-related cognitive impairments, including dementia.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/32111938
関連名称 32111938
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-020-60781-1
関連名称 10.1038/s41598-020-60781-1
権利
権利情報 © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000563057000007
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