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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam

http://hdl.handle.net/10091/00022531
a82d1ceb-dd24-40df-b345-72bec3b1ab9a
名前 / ファイル ライセンス アクション
15K06754_01.pdf 15K06754_01.pdf (2.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-16
タイトル
言語 en
タイトル Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam
言語
言語 eng
キーワード
主題Scheme Other
主題 Guam parkinsonism-dementia complex
キーワード
主題Scheme Other
主題 mutant ubiquitin
キーワード
主題Scheme Other
主題 protein quality control
キーワード
主題Scheme Other
主題 protein aggregation
キーワード
主題Scheme Other
主題 tau
キーワード
主題Scheme Other
主題 neurofibrillary tangles
キーワード
主題Scheme Other
主題 43-kDa TAR DNA-binding protein
キーワード
主題Scheme Other
主題 neuropathology
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Verheijen, Bert M.

× Verheijen, Bert M.

WEKO 110318

en Verheijen, Bert M.

Search repository
Oyanagi, Kiyomitsu

× Oyanagi, Kiyomitsu

WEKO 110319

en Oyanagi, Kiyomitsu

Search repository
van, Leeuwen Fred W.

× van, Leeuwen Fred W.

WEKO 110320

en van, Leeuwen Fred W.

Search repository
信州大学研究者総覧へのリンク
氏名 Oyanagi, Kiyomitsu
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.jhTCPpym.html
出版者
出版者 FRONTIERS MEDIA SA
引用
内容記述タイプ Other
内容記述 FRONTIERS IN NEUROLOGY.9:173(2018)
書誌情報 FRONTIERS IN NEUROLOGY

巻 9, p. 173, 発行日 2018-03-20
抄録
内容記述タイプ Abstract
内容記述 Guam parkinsonism-dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologically, G-PDC is characterized by abundant neurofibrillary tangles, which are composed of hyperphosphorylated tau, marked deposition of 43-kDa TAR DNA-binding protein, and neuronal loss. Although both genetic and environmental factors have been implicated, the etiology and pathogenesis of G-PDC remain unknown. Recent neuropathological studies have provided new clues about the pathomechanisms involved in G-PDC. For example, deposition of abnormal components of the protein quality control system in brains of G-PDC patients indicates a role for proteostasis imbalance in the disease. This opens up promising avenues for new research on G-PDC and could have important implications for the study of other neurodegenerative disorders.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 1664-2295
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/29615966
関連名称
関連名称 29615966
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3389/fneur.2018.00173
関連名称
関連名称 10.3389/fneur.2018.00173
権利
権利情報 Copyright © 2018 Verheijen, Oyanagi and van Leeuwen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000427879500001
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