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Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam
http://hdl.handle.net/10091/00022531
http://hdl.handle.net/10091/00022531a82d1ceb-dd24-40df-b345-72bec3b1ab9a
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-16 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Guam parkinsonism-dementia complex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mutant ubiquitin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein quality control | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein aggregation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tau | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neurofibrillary tangles | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 43-kDa TAR DNA-binding protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neuropathology | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Verheijen, Bert M.
× Verheijen, Bert M.× Oyanagi, Kiyomitsu× van, Leeuwen Fred W. |
|||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Oyanagi, Kiyomitsu | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.jhTCPpym.html | |||||
出版者 | ||||||
出版者 | FRONTIERS MEDIA SA | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | FRONTIERS IN NEUROLOGY.9:173(2018) | |||||
書誌情報 |
FRONTIERS IN NEUROLOGY 巻 9, p. 173, 発行日 2018-03-20 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Guam parkinsonism-dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologically, G-PDC is characterized by abundant neurofibrillary tangles, which are composed of hyperphosphorylated tau, marked deposition of 43-kDa TAR DNA-binding protein, and neuronal loss. Although both genetic and environmental factors have been implicated, the etiology and pathogenesis of G-PDC remain unknown. Recent neuropathological studies have provided new clues about the pathomechanisms involved in G-PDC. For example, deposition of abnormal components of the protein quality control system in brains of G-PDC patients indicates a role for proteostasis imbalance in the disease. This opens up promising avenues for new research on G-PDC and could have important implications for the study of other neurodegenerative disorders. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1664-2295 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/29615966 | |||||
関連名称 | 29615966 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3389/fneur.2018.00173 | |||||
関連名称 | 10.3389/fneur.2018.00173 | |||||
権利 | ||||||
権利情報 | Copyright © 2018 Verheijen, Oyanagi and van Leeuwen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000427879500001 |