{"created":"2021-03-01T06:24:55.869030+00:00","id":21774,"links":{},"metadata":{"_buckets":{"deposit":"21b36197-2d69-48da-8889-c8a1112a5a7d"},"_deposit":{"id":"21774","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21774"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00021774","sets":["461:462"]},"author_link":["110318","110319","110320"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"173","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"FRONTIERS IN NEUROLOGY"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Guam parkinsonism-dementia complex (G-PDC) is an enigmatic neurodegenerative disease that is endemic to the Pacific island of Guam. G-PDC patients are clinically characterized by progressive cognitive impairment and parkinsonism. Neuropathologically, G-PDC is characterized by abundant neurofibrillary tangles, which are composed of hyperphosphorylated tau, marked deposition of 43-kDa TAR DNA-binding protein, and neuronal loss. Although both genetic and environmental factors have been implicated, the etiology and pathogenesis of G-PDC remain unknown. Recent neuropathological studies have provided new clues about the pathomechanisms involved in G-PDC. For example, deposition of abnormal components of the protein quality control system in brains of G-PDC patients indicates a role for proteostasis imbalance in the disease. This opens up promising avenues for new research on G-PDC and could have important implications for the study of other neurodegenerative disorders.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"FRONTIERS IN NEUROLOGY.9:173(2018)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Oyanagi, Kiyomitsu","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.jhTCPpym.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000427879500001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"FRONTIERS MEDIA SA"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"29615966"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/29615966","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3389/fneur.2018.00173"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fneur.2018.00173","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2018 Verheijen, Oyanagi and van Leeuwen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1664-2295","subitem_source_identifier_type":"EISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Verheijen, Bert M.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oyanagi, Kiyomitsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"van, Leeuwen  Fred W.","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-16"}],"displaytype":"detail","filename":"15K06754_01.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensefree":"Copyright © 2018 Verheijen, Oyanagi and van Leeuwen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K06754_01.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/21774/files/15K06754_01.pdf"},"version_id":"f6f91085-5893-4d27-9b2b-f21934f4df30"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Guam parkinsonism-dementia complex","subitem_subject_scheme":"Other"},{"subitem_subject":"mutant ubiquitin","subitem_subject_scheme":"Other"},{"subitem_subject":"protein quality control","subitem_subject_scheme":"Other"},{"subitem_subject":"protein aggregation","subitem_subject_scheme":"Other"},{"subitem_subject":"tau","subitem_subject_scheme":"Other"},{"subitem_subject":"neurofibrillary tangles","subitem_subject_scheme":"Other"},{"subitem_subject":"43-kDa TAR DNA-binding protein","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathology","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-16"},"publish_date":"2021-02-16","publish_status":"0","recid":"21774","relation_version_is_last":true,"title":["Dysfunction of Protein Quality control in Parkinsonism-Dementia complex of Guam"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:27:11.782663+00:00"}