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The goal of the study was to examine the possibility of plasma cytokines for the screening of colorectal cancer (CRC). Methods We carried out a multicenter, hospital-based case-control study in 66 adult Japanese patients with CRC and 87 healthy adult Japanese. A multiplex bead array immunoassay was used to examine 27 different plasma cytokines. Their association with the presence of CRC was evaluated by logistic regression analysis after adjusting for potential confounding factors. Results Thirteen plasma cytokines were notably associated with the presence of CRC (p\u003c 0.05). Receiver operating characteristic analysis revealed that the combinatorial assessment of some of these plasma cytokines showed \"good\" capability for discriminating between CRC patients and control subjects (area under the curve (AUC): 0.819 for the combination of IL-9, Eotaxin, G-CSF, and TNF-alpha; 0.832 for the combination of IL-4, IL-8, Eotaxin, IP-10, and TNF-alpha). 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Plasma cytokine levels and the presence of colorectal cancer
http://hdl.handle.net/10091/00022724
http://hdl.handle.net/10091/000227242a694213-4a16-44dc-bfc7-2fc52e996832
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-22 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Plasma cytokine levels and the presence of colorectal cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yamaguchi, Masaki
× Yamaguchi, Masaki× Okamura, Shin× Yamaji, Taiki× Iwasaki, Motoki× Tsugane, Shoichiro× Shetty, Vivek× Koizumi, Tomonobu |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Yamaguchi, Masaki | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.HhLFZeLe.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Koizumi, Tomonobu | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html | |||||
出版者 | ||||||
出版者 | PUBLIC LIBRARY SCIENCE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLOS ONE.14(3):e0213602(2019) | |||||
書誌情報 |
PLOS ONE 巻 14, 号 3, p. e0213602, 発行日 2019-03-18 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aims Cancer-related activation of cytokine networks are central aspects of tumor development. The goal of the study was to examine the possibility of plasma cytokines for the screening of colorectal cancer (CRC). Methods We carried out a multicenter, hospital-based case-control study in 66 adult Japanese patients with CRC and 87 healthy adult Japanese. A multiplex bead array immunoassay was used to examine 27 different plasma cytokines. Their association with the presence of CRC was evaluated by logistic regression analysis after adjusting for potential confounding factors. Results Thirteen plasma cytokines were notably associated with the presence of CRC (p< 0.05). Receiver operating characteristic analysis revealed that the combinatorial assessment of some of these plasma cytokines showed "good" capability for discriminating between CRC patients and control subjects (area under the curve (AUC): 0.819 for the combination of IL-9, Eotaxin, G-CSF, and TNF-alpha; 0.832 for the combination of IL-4, IL-8, Eotaxin, IP-10, and TNF-alpha). Individual cytokine assessments presented lower AUCs (0.657-0.755) than the combinatorial cytokine assessments. Conclusions The levels of several plasma cytokines varied significantly between CRC patients and control subjects, suggesting the possibility of differentially expressed plasma cytokines as potential biomarkers for detecting the presence of CRC. Our results should be validated in other populations. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1932-6203 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://www.ncbi.nlm.nih.gov/pubmed/30883594 | |||||
関連名称 | 30883594 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1371/journal.pone.0213602 | |||||
関連名称 | 10.1371/journal.pone.0213602 | |||||
権利 | ||||||
権利情報 | © 2019 Yamaguchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000461423500022 |