{"created":"2021-03-01T06:25:08.030139+00:00","id":21970,"links":{},"metadata":{"_buckets":{"deposit":"776dc9ff-54ba-4305-aa65-525431061a19"},"_deposit":{"id":"21970","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21970"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00021970","sets":["1309:1310"]},"author_link":["110784","110785","110786"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"3582","bibliographicPageStart":"3570","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF INTERNATIONAL MEDICAL RESEARCH"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective To develop a combinatorial panel of salivary cytokines that manifests the presence of non-small cell lung cancer (NSCLC) that will eventually improve prognosis by facilitating the early diagnosis and management of this common cancer. Methods We performed a case-control study comparing salivary cytokine profiles of 35 adult subjects with NSCLC with those of 35 matched, healthy nonsmokers. Multiplex bead array assays were used to quantify 27 cytokines in saliva, serum, and oral mucosal transudate samples. Logistic regression analysis was used to develop an informative cytokine panel. Receiver operating characteristic (ROC) curves were generated to evaluate the discriminant ability of the panel. Results A combinatorial 12-cytokine panel (interleukin receptor antagonist [IL1RN], IL1B, IL6, IL7, IL8, IL10, C-C motif chemokine ligand 11 [CCL11], tumor necrosis factor, C-X-C motif chemokine ligand 10 [CXCL10], C-C motif chemokine ligand 3, C-C motif chemokine ligand 4, and platelet-derived growth factor-BB) distinguished patients with NSCLC from healthy controls. Further, ROC analysis revealed that a cytokine panel comprising IL10 (odds ratio, 1.156) and CXCL10 (odds ratio, 1.000) discriminated NSCLC with a sensitivity of 60.6% and specificity of 80.8% (area under the ROC curve, 0.701). Conclusion A combinatorial panel of select salivary cytokines indicates the presence of NSCLC.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.46(9):3570-3582(2018)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Koizumi, Tomonobu","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html"},{"subitem_link_text":"Yamaguchi, Masaki","subitem_link_url":"https://soar-rd.shinshu-u.ac.jp/profile/ja.HhLFZeLe.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000443978100006"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE PUBLICATIONS LTD"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"29916282"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pubmed/29916282","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1177/0300060518775563"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1177/0300060518775563","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2018. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage)."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-0605","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00700686","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koizumi, Tomonobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shetty, Vivek"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Masaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-22"}],"displaytype":"detail","filename":"16H03166_04.pdf","filesize":[{"value":"395.6 kB"}],"format":"application/pdf","licensefree":"© The Author(s) 2018. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16H03166_04.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/21970/files/16H03166_04.pdf"},"version_id":"46801eb6-e608-4eac-adbd-2dd6be0fee5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"saliva","subitem_subject_scheme":"Other"},{"subitem_subject":"non-small cell lung cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"logistic regression analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"oral mucosal transudate","subitem_subject_scheme":"Other"},{"subitem_subject":"combinatorial panel","subitem_subject_scheme":"Other"},{"subitem_subject":"multiplex analysis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Salivary cytokine panel indicative of non-small cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Salivary cytokine panel indicative of non-small cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["1310"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-02-22"},"publish_date":"2021-02-22","publish_status":"0","recid":"21970","relation_version_is_last":true,"title":["Salivary cytokine panel indicative of non-small cell lung cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:19:58.270695+00:00"}