{"created":"2021-03-01T06:04:48.867948+00:00","id":362,"links":{},"metadata":{"_buckets":{"deposit":"d243bb5a-3a9f-42e1-928b-d5da749ddedd"},"_deposit":{"id":"362","owners":[],"pid":{"revision_id":0,"type":"depid","value":"362"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00000362","sets":["30:31"]},"author_link":["919","920","921","922","923","924","925","926","927","928","929","930","931","932","933","934"],"control_number":"362","item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"3497","bibliographicPageStart":"3487","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"International Journal of Nanomedicine"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined differences in cellular responses to multi-walled carbon nanotubes (MWCNTs) using malignant pleural mesothelioma cells (MESO-1), bronchial epithelial cells (BEAS-2B), neuroblastoma cells (IMR-32), and monoblastic cells (THP-1), before and after differentiation. MESO-1, BEAS-2B and differentiated THP-1 cells actively endocytosed MWCNTs, resulting in cytotoxicity with lysosomal injury. However, cytotoxicity did not occur in IMR-32 or undifferentiated THP-1 cells. Both differentiated and undifferentiated THP-1 cells exhibited an inflammatory response. Carbon blacks were endocytosed by the same cell types without lysosomal damage and caused cytokine secretion, but they did not cause cytotoxicity. These results indicate that the cytotoxicity of MWCNTs requires not only cellular uptake but also lysosomal injury. Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"International Journal of Nanomedicine. 6(1):3487-3497 (2011)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Haniu, Hisao","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"},{"subitem_link_text":"Saito, Naoto","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html"},{"subitem_link_text":"Kato, Hiroyuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000298288600001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dove Medical Press"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"22267932"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/22267932/","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.2147/IJN.S26689"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2147/IJN.S26689","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2011 Haniu et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1176-9114","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1215861X","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Haniu,  Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito,  Naoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda,  Yoshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kim,  Yoong-Ahm","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Park,  Ki Chul","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsukahara,  Tamotsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Usui,  Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki,  Kaoru","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu,  Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogihara,  Nobuhide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hara,  Kazuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takanashi,  Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto,  Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishigaki,  Norio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura,  Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato,  Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-18"}],"displaytype":"detail","filename":"Elucidation_mechanism_different_biological_responses.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"Elucidation_mechanism_different_biological_responses.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/362/files/Elucidation_mechanism_different_biological_responses.pdf"},"version_id":"1838169d-dd02-4589-99f4-67636ae9ae0b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ulti-walled carbon nanotubes","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxicity","subitem_subject_scheme":"Other"},{"subitem_subject":"endocytosis","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine secretion","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["31"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-01-16"},"publish_date":"2012-01-16","publish_status":"0","recid":"362","relation_version_is_last":true,"title":["Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines"],"weko_creator_id":"1","weko_shared_id":3},"updated":"2022-12-14T03:56:46.677154+00:00"}