ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "2162a056-d479-4968-a4f2-23450d16cb10"}, "_deposit": {"id": "366", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "366"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00000366", "sets": ["30:31"]}, "author_link": ["976", "977", "978", "979", "980", "981"], "control_number": "366", "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-02-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "262", "bibliographicPageStart": "256", "bibliographicVolumeNumber": "242", "bibliographic_titles": [{"bibliographic_title": "Toxicology and Applied Pharmacology"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "This study evaluated the biological responses to multi-walled carbon nanotubes (MWCNTs). Human monoblastic leukemia cells (U937) were exposed to As-grown MWCNTs and MWCNTs that were thermally treated at 1800 degrees C (HTT1800) and 2800 degrees C (HTT2800). Cell proliferation was highly inhibited by As-grown but not HTT2800. However, both As-grown and HTT1800, which include some impurities, were cytotoxic. Proteomics analysis of MWCNT-exposed cells revealed 37 protein spots on 2-dimensional electrophoresis gels that significantly changed (p\u003c0.05) after exposure to HTT1800 with a little iron and 20 spots that changed after exposure to HTT2800. Peptide mass fingerprinting identified 45 proteins that included heat shock protein beta-1, neutral alpha-glucosidase AB, and DNA mismatch repair protein Msh2. These altered proteins play roles in metabolism, biosynthesis, response to stress, and cell differentiation. Although HTT2800 did not inhibit cell proliferation or cause cytotoxicity in vitro, some proteins related to the response to stress were changed. Moreover, DJ-1 protein, which is a biomarker of Parkinson\u0027s disease and is related to cancer, was identified after exposure to both MWCNTs. These results show that the cytotoxicity of MWCNTs depends on their impurities, such as iron, while MWCNTs themselves cause some biological responses directly and/or indirectly in vitro. Our proteomics-based approach for detecting biological responses to nanomaterials is a promising new method for detailed safety evaluations.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "Toxicology and Applied Pharmacology. 242(3):256-262 (2010)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Haniu, Hisao", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html"}, {"subitem_link_text": "Hayashi, Takuya", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jmLUbpkh.html"}, {"subitem_link_text": "Endo, Morinobu", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uUTmZhkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000273832500003"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "ACADEMIC PRESS INC ELSEVIER SCIENCE"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "19874835"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/19874835/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.taap.2009.10.015"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.taap.2009.10.015", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright \u00a9 2009 Elsevier Inc."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0041-008X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0041-008X", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00864435", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Carbon nanotubes; Safety evaluation; Proteomics; Protein expression; In vitro"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "PARKINSONS-DISEASE; OXIDATIVE STRESS; EPITHELIAL-CELLS; C57BL/6 MICE; LUNG; CYTOTOXICITY; TOXICITY; EXPOSURE; CANCER; MOUSE"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "This study evaluated the biological responses to multi-walled carbon nanotubes (MWCNTs). Human monoblastic leukemia cells (U937) were exposed to As-grown MWCNTs and MWCNTs that were thermally treated at 1800 degrees C (HTT1800) and 2800 degrees C (HTT2800). Cell proliferation was highly inhibited by As-grown but not HTT2800. However, both As-grown and HTT1800, which include some impurities, were cytotoxic. Proteomics analysis of MWCNT-exposed cells revealed 37 protein spots on 2-dimensional electrophoresis gels that significantly changed (p\u003c0.05) after exposure to HTT1800 with a little iron and 20 spots that changed after exposure to HTT2800. Peptide mass fingerprinting identified 45 proteins that included heat shock protein beta-1, neutral alpha-glucosidase AB, and DNA mismatch repair protein Msh2. These altered proteins play roles in metabolism, biosynthesis, response to stress, and cell differentiation. Although HTT2800 did not inhibit cell proliferation or cause cytotoxicity in vitro, some proteins related to the response to stress were changed. Moreover, DJ-1 protein, which is a biomarker of Parkinson\u0027s disease and is related to cancer, was identified after exposure to both MWCNTs. These results show that the cytotoxicity of MWCNTs depends on their impurities, such as iron, while MWCNTs themselves cause some biological responses directly and/or indirectly in vitro. Our proteomics-based approach for detecting biological responses to nanomaterials is a promising new method for detailed safety evaluations. (C) 2009 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Haniu,  Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  Yoshikazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi,  Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kim,  Yoong Ahm", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi,  Takuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo,  Morinobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "981", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Proteomics-Based_Safety_Evaluation.pdf", "filesize": [{"value": "367.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 367800.0, "url": {"label": "Proteomics-Based_Safety_Evaluation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/366/files/Proteomics-Based_Safety_Evaluation.pdf"}, "version_id": "a0a59738-17db-46d8-83a1-ebb6d628f4ee"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Carbon nanotubes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Safety evaluation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Proteomics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Protein expression", "subitem_subject_scheme": "Other"}, {"subitem_subject": "In vitro", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Proteomics-based safety evaluation of multi-walled carbon nanotubes", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Proteomics-based safety evaluation of multi-walled carbon nanotubes", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["30/31"], "permalink_uri": "http://hdl.handle.net/10091/10727", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-10-25"}, "publish_date": "2010-10-25", "publish_status": "0", "recid": "366", "relation": {}, "relation_version_is_last": true, "title": ["Proteomics-based safety evaluation of multi-walled carbon nanotubes"], "weko_shared_id": -1}
  1. 130 カーボン科学研究所
  2. 1301 学術論文

Proteomics-based safety evaluation of multi-walled carbon nanotubes

http://hdl.handle.net/10091/10727
344422d9-90cd-44a6-bd5d-249f8ee0ea7a
名前 / ファイル ライセンス アクション
Proteomics-Based_Safety_Evaluation.pdf Proteomics-Based_Safety_Evaluation.pdf (367.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-10-25
タイトル
言語 en
タイトル Proteomics-based safety evaluation of multi-walled carbon nanotubes
言語
言語 eng
キーワード
主題Scheme Other
主題 Carbon nanotubes
キーワード
主題Scheme Other
主題 Safety evaluation
キーワード
主題Scheme Other
主題 Proteomics
キーワード
主題Scheme Other
主題 Protein expression
キーワード
主題Scheme Other
主題 In vitro
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Haniu, Hisao

× Haniu, Hisao

WEKO 976

en Haniu, Hisao

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 977

en Matsuda, Yoshikazu

Search repository
Takeuchi, Kenji

× Takeuchi, Kenji

WEKO 978

en Takeuchi, Kenji

Search repository
Kim, Yoong Ahm

× Kim, Yoong Ahm

WEKO 979

en Kim, Yoong Ahm

Search repository
Hayashi, Takuya

× Hayashi, Takuya

WEKO 980

en Hayashi, Takuya

Search repository
Endo, Morinobu

× Endo, Morinobu

WEKO 981

en Endo, Morinobu

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Hayashi, Takuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jmLUbpkh.html
信州大学研究者総覧へのリンク
氏名 Endo, Morinobu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uUTmZhkh.html
出版者
出版者 ACADEMIC PRESS INC ELSEVIER SCIENCE
引用
内容記述タイプ Other
内容記述 Toxicology and Applied Pharmacology. 242(3):256-262 (2010)
書誌情報 Toxicology and Applied Pharmacology

巻 242, 号 3, p. 256-262, 発行日 2010-02-01
抄録
内容記述タイプ Abstract
内容記述 This study evaluated the biological responses to multi-walled carbon nanotubes (MWCNTs). Human monoblastic leukemia cells (U937) were exposed to As-grown MWCNTs and MWCNTs that were thermally treated at 1800 degrees C (HTT1800) and 2800 degrees C (HTT2800). Cell proliferation was highly inhibited by As-grown but not HTT2800. However, both As-grown and HTT1800, which include some impurities, were cytotoxic. Proteomics analysis of MWCNT-exposed cells revealed 37 protein spots on 2-dimensional electrophoresis gels that significantly changed (p<0.05) after exposure to HTT1800 with a little iron and 20 spots that changed after exposure to HTT2800. Peptide mass fingerprinting identified 45 proteins that included heat shock protein beta-1, neutral alpha-glucosidase AB, and DNA mismatch repair protein Msh2. These altered proteins play roles in metabolism, biosynthesis, response to stress, and cell differentiation. Although HTT2800 did not inhibit cell proliferation or cause cytotoxicity in vitro, some proteins related to the response to stress were changed. Moreover, DJ-1 protein, which is a biomarker of Parkinson's disease and is related to cancer, was identified after exposure to both MWCNTs. These results show that the cytotoxicity of MWCNTs depends on their impurities, such as iron, while MWCNTs themselves cause some biological responses directly and/or indirectly in vitro. Our proteomics-based approach for detecting biological responses to nanomaterials is a promising new method for detailed safety evaluations.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0041-008X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00864435
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19874835/
関連名称
関連名称 19874835
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.taap.2009.10.015
関連名称
関連名称 10.1016/j.taap.2009.10.015
権利
権利情報 Copyright © 2009 Elsevier Inc.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000273832500003
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 15:12:36.129523
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio