@article{oai:soar-ir.repo.nii.ac.jp:00003665,
 author = {Takanashi,  Seiji and Hara,  Kazuo and Aoki,  Kaoru and Usui,  Yuki and Shimizu,  Masayuki and Haniu,  Hisao and Ogihara,  Nobuhide and Ishigaki,  Norio and Nakamura,  Koichi and Okamoto,  Masanori and Kobayashi,  Shinsuke and Kato,  Hiroyuki and Sano,  Kenji and Nishimura,  Naoyuki and Tsutsumi,  Hideki and Machida,  Kazuhiko and Saito,  Naoto},
 journal = {SCIENTIFIC REPORTS},
 month = {Jul},
 note = {The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxicity evaluations are required. Among these evaluations, carcinogenicity should be examined with the highest priority; however, no report using transgenic mice to evaluate the carcinogenicity of CNTs has been published to date. Here, we performed a carcinogenicity test by implanting multi-walled CNTs (MWCNTs) into the subcutaneous tissue of rasH2 mice, using the carbon black present in black tattoo ink as a reference material for safety. The rasH2 mice did not develop neoplasms after being injected with MWCNTs; instead, MWCNTs showed lower carcinogenicity than carbon black. Such evaluations should facilitate the clinical application and development of CNTs for use in important medical fields., Article, SCIENTIFIC REPORTS. 2:498 (2012)},
 title = {Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice},
 volume = {2},
 year = {2012}
}