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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Cold stress induces lower urinary tract symptoms

http://hdl.handle.net/10091/17870
http://hdl.handle.net/10091/17870
3027e74b-965e-49d6-a2bf-691496ef06e8
名前 / ファイル ライセンス アクション
Cold_stress_induces_lower_urinary.pdf Cold_stress_induces_lower_urinary.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-09-05
タイトル
言語 en
タイトル Cold stress induces lower urinary tract symptoms
言語
言語 eng
キーワード
主題Scheme Other
主題 C-fiber
キーワード
主題Scheme Other
主題 cold stress
キーワード
主題Scheme Other
主題 detrusor overactivity
キーワード
主題Scheme Other
主題 lower urinary tract symptoms
キーワード
主題Scheme Other
主題 transient receptor potential melastatin 8 channel
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Imamura, Tetsuya

× Imamura, Tetsuya

WEKO 6216

en Imamura, Tetsuya

Search repository
Ishizuka, Osamu

× Ishizuka, Osamu

WEKO 6217

en Ishizuka, Osamu

Search repository
Nishizawa, Osamu

× Nishizawa, Osamu

WEKO 6218

en Nishizawa, Osamu

Search repository
信州大学研究者総覧へのリンク
氏名 Imamura, Tetsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html
信州大学研究者総覧へのリンク
氏名 Ishizuka, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 INTERNATIONAL JOURNAL OF UROLOGY. 20(7):661-669 (2013)
書誌情報 INTERNATIONAL JOURNAL OF UROLOGY

巻 20, 号 7, p. 661-669, 発行日 2013-07
抄録
内容記述タイプ Abstract
内容記述 Cold stress as a result of whole-body cooling at low environmental temperatures exacerbates lower urinary tract symptoms, such as urinary urgency, nocturia and residual urine. We established a model system using healthy conscious rats to explore the mechanisms of cold stress-induced detrusor overactivity. In this review, we summarize the basic findings shown by this model. Rats that were quickly transferred from room temperature (27 +/- 2 degrees C) to low temperature (4 +/- 2 degrees C) showed detrusor overactivity including increased basal pressure and decreased voiding interval, micturition volume, and bladder capacity. The cold stress-induced detrusor overactivity is mediated through a resiniferatoxin-sensitve C-fiber sensory nerve pathway involving 1-adrenergic receptors. Transient receptor potential melastatin8 channels, which are sensitive to thermal changes below 25-28 degrees C, also play an important role in mediating the cold stress responses. Additionally, the sympathetic nervous system is associated with transient hypertension and decreases of skin surface temperature that are closely correlated with the detrusor overactivity. With this cold stress model, we showed that 1-adrenergic receptor antagonists have the potential to treat cold stress-exacerbated lower urinary tract symptoms. In addition, we showed that traditional Japanese herbal mixtures composed of Hachimijiogan act, in part, by increasing skin temperature and reducing the number of cold sensitive transient receptor potential melastatin channels in the skin. The effects of herbal mixtures have the potential to treat and/or prevent the exacerbation of lower urinary tract symptoms by providing resistance to the cold stress responses. Our model provides new opportunities for utilizing animal disease models with altered lower urinary tract functions to explore the effects of novel therapeutic drugs.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0919-8172
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11042471
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/23441811
関連名称 23441811
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/iju.12129
関連名称 10.1111/iju.12129
権利
権利情報 Copyright© 2013 The Japanese Urological Association
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000321619900005
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