{"created":"2021-03-01T06:07:30.471071+00:00","id":3676,"links":{},"metadata":{"_buckets":{"deposit":"ae3f5ba8-6a22-40d8-b240-a1f0fa08eab4"},"_deposit":{"id":"3676","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3676"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00003676","sets":["461:462"]},"author_link":["6248","6249","6250"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The CE/J mouse strain is resistant to amyloid A protein (AA) amyloidosis. In contrast to AA amyloidosis-susceptible mouse strains that concomitantly express serum amyloid A precursor protein (SAA) types 1 and 2 isoforms encoded by the Saa1 and Saa2 genes, respectively, in response to inflammatory stimulation from the liver, CE/J mice express only a single SAA isoform named SAA2.2. In addition, CE/J mice uniquely possess a Q30L amino acid substitution in SAA2.2 that inhibits amyloidogenesis. To elucidate the genetic basis underlying the expression of only a single SAA isoform in this strain, we conducted PCR cloning and nucleotide sequencing of the Saa1 and Saa2 genes from the CE/J genome. We revealed that CE/J mice possess functional Saa1 and Saa2 genes. Intriguingly, the two genes were identical with respect to amino acid sequence, each encoding the SAA2.2 isoform. RT-PCR analysis of inflamed liver tissue from CE/J mice demonstrated that both genes are expressed at equivalent levels. Reporter assays revealed that promoter/enhancer sequences of Saa1 and Saa2 genes in CE/J are also functional. These results indicate that the SAA2.2 isoform in CE/J is a mixture of Saa1 and Saa2 gene products.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 21(1):1-8 (2014)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Mori, Masayuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html"},{"subitem_link_text":"Higuchi, Keiichi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000335764200001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"INFORMA HEALTHCARE"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"24228751"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/24228751","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3109/13506129.2013.852529"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3109/13506129.2013.852529","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© 2014 Informa Healthcare"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1350-6129","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11096426","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori,  Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tiang,  Geng","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi,  Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"AA_amyloidosis-resistant_CE_J_mice.pdf","filesize":[{"value":"696.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA_amyloidosis-resistant_CE_J_mice.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/3676/files/AA_amyloidosis-resistant_CE_J_mice.pdf"},"version_id":"b3efec06-1ae6-436e-a3fe-de6a606c462e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amino acid substitution","subitem_subject_scheme":"Other"},{"subitem_subject":"gene conversion","subitem_subject_scheme":"Other"},{"subitem_subject":"gene family","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse strain","subitem_subject_scheme":"Other"},{"subitem_subject":"nucleotide substitution","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-09-05"},"publish_date":"2014-09-05","publish_status":"0","recid":"3676","relation_version_is_last":true,"title":["AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:40:12.243915+00:00"}