@article{oai:soar-ir.repo.nii.ac.jp:00003691,
 author = {Sasayama,  Daimei and Hori,  Hiroaki and Teraishi,  Toshiya and Hattori,  Kotaro and Ota,  Miho and Matsuo,  Junko and Kawamoto,  Yumiko and Kinoshita,  Yukiko and Higuchi,  Teruhiko and Amano,  Naoji and Kunugi,  Hiroshi},
 issue = {8},
 journal = {JOURNAL OF HUMAN GENETICS},
 month = {Aug},
 note = {Interleukin-1 beta (IL-1 beta) is considered to have a role in age-related cognitive decline. A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (>= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. Journal of Human Genetics (2011) 56, 613-616; doi:10.1038/jhg.2011.56; published online 26 May 2011, Article, JOURNAL OF HUMAN GENETICS. 56(8):613-616 (2011)},
 pages = {613--616},
 title = {Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia},
 volume = {56},
 year = {2011}
}