{"created":"2021-03-01T06:07:34.921900+00:00","id":3748,"links":{},"metadata":{"_buckets":{"deposit":"4536e65f-631a-4792-b12d-9c063e852e6a"},"_deposit":{"id":"3748","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3748"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00003748","sets":["461:462"]},"author_link":["6774","6775","6776","6777","6778"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"525","bibliographicPageStart":"519","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"ENDOCRINE JOURNAL"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Pancreatic beta cell dysfunction is pivotal to the development of diabetes, and restoration of insulin action is of primary importance. Here, we present a review of the mechanism of insulin secretion by pancreatic beta cells and discuss the mutual interaction of signaling pathways in stimulus-secretion coupling to better understand the scientific basis of pharmacological treatment for insulin secretion deficiency. Glucose stimulates insulin secretion via membrane depolarization by closure of ATP-sensitive K(+) channels (K(ATP) channels) and opening of L-type voltage-dependent Ca(2+) channels. The resultant elevation of cytosolic free Ca2+ triggers insulin exocytosis. This is termed the \"K(ATP)-dependent pathway\" and is shared by sulfonylurea, which closes K(ATP) channels. Glucose also stimulates insulin release independent of its action on K(ATP) channels. This is referred to as the \"K(ATP)-independent pathway,\" the molecular basis of which remains elusive. In the pancreatic beta cell, incretin hormones increase cAMP level, which enhances glucose-stimulated insulin release by protein kinase A-dependent and -independent mechanisms. Importantly, cAMP does not directly augment Ca(2+)-stimulated insulin release per se. The stimulatory level of ambient glucose is an absolute requirement for incretin to enhance insulin release. Therefore, incretin/cAMP enhances K(ATP)-independent insulinotropic action of glucose. The robust glucose-lowering effect of DPP4 inhibitor add-on in diabetic patients with sulfonylurea secondary failure is intriguing. With the clinical availability of DPP4 inhibitor and GLP-1 mimetics, the importance of the interactions between cAMP signaling and K(ATP) channel-independent actions of glucose is reappraised.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"ENDOCRINE JOURNAL. 58(7):519-525 (2011)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Nishio, Shinichi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.janagUkh.html"},{"subitem_link_text":"Komatsu, Mitsuhisa","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.HUnpHVkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294533900001"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"JAPAN ENDOCRINE SOC"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"21701075"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/21701075","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1507/endocrj.EJ11-0064"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1507/endocrj.EJ11-0064","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright© The Japan Endocrine Society"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-8959","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10901436","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishii,  Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato,  Yoshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei,  Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishio,  Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komatsu,  Mitsuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6778","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Glucose-incretin_interaction_revisited.pdf","filesize":[{"value":"989.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Glucose-incretin_interaction_revisited.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/3748/files/Glucose-incretin_interaction_revisited.pdf"},"version_id":"565b1e9c-d1ed-4e2e-b892-628dd7f0df5d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glucose","subitem_subject_scheme":"Other"},{"subitem_subject":"Insulin secretion","subitem_subject_scheme":"Other"},{"subitem_subject":"ATP-sensitive K(+) channel","subitem_subject_scheme":"Other"},{"subitem_subject":"Incretin","subitem_subject_scheme":"Other"},{"subitem_subject":"cAMP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Glucose-incretin interaction revisited","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glucose-incretin interaction revisited","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-09"},"publish_date":"2014-06-09","publish_status":"0","recid":"3748","relation_version_is_last":true,"title":["Glucose-incretin interaction revisited"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:39:38.174386+00:00"}