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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells

http://hdl.handle.net/10091/17331
00a69535-2264-42e6-b92e-fa0eb4f4560a
名前 / ファイル ライセンス アクション
PSF_Knockdown_Enhances_Apoptosis_Downregulation.pdf PSF_Knockdown_Enhances_Apoptosis_Downregulation.pdf (3.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-01-21
タイトル
言語 en
タイトル PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 6952

en Tsukahara, Tamotsu

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 6953

en Matsuda, Yoshikazu

Search repository
Haniu, Hisao

× Haniu, Hisao

WEKO 6954

en Haniu, Hisao

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述タイプ Other
内容記述 BIOMED RESEARCH INTERNATIONAL. 2013:204973 (2013)
書誌情報 BIOMED RESEARCH INTERNATIONAL

巻 2013, p. 204973, 発行日 2013-01
抄録
内容記述タイプ Abstract
内容記述 Our previous study demonstrated that PTB-associated splicing factor (PSF) is an important regulator of cell death and plays critical roles in the survival and growth of colon cancer cells. However, the molecular mechanism that activates these downstream signaling events remains unknown. To address this issue, we investigated the effects of PSF knockdown in two different colon cancer cell lines, DLD-1 and HT-29. We found that knockdown of PSF markedly decreased the autophagic molecule LC3B in DLD-1 cells but not in HT-29 cells. Furthermore, DLD-1 cells were more susceptible to PSF knockdown-induced cell growth inhibition and apoptosis than HT-29 cells. This susceptibility is probably a result of LC3B inhibition, given the known relationship between autophagy and apoptosis. C3B is associated with a number of physiological processes, including cell growth and apoptotic cell death. Our results suggest that autophagy is inhibited by PSF knockdown and that apoptosis and cell growth inhibition may act together to mediate the PSF-LC3B signaling pathway. Furthermore, we found that the peroxisome proliferator-activated receptor gamma (PPAR gamma)-PSF complex induced LC3B downregulation in DLD-1 cells. The results of this study identify a new physiological role for the PSF-LC3B axis as a potential endogenous modulator of colon cancer treatment.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 2314-6133
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24288667/
関連名称
関連名称 24288667
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2013/204973
関連名称
関連名称 10.1155/2013/204973
権利
権利情報 Copyright© 2013 Tamotsu Tsukahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000326788000001
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