WEKO3
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PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells
http://hdl.handle.net/10091/17331
http://hdl.handle.net/10091/1733100a69535-2264-42e6-b92e-fa0eb4f4560a
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-01-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Matsuda, Yoshikazu× Haniu, Hisao |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Haniu, Hisao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
出版者 | ||||||
出版者 | HINDAWI PUBLISHING CORPORATION | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BIOMED RESEARCH INTERNATIONAL. 2013:204973 (2013) | |||||
書誌情報 |
BIOMED RESEARCH INTERNATIONAL 巻 2013, p. 204973, 発行日 2013-01 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Our previous study demonstrated that PTB-associated splicing factor (PSF) is an important regulator of cell death and plays critical roles in the survival and growth of colon cancer cells. However, the molecular mechanism that activates these downstream signaling events remains unknown. To address this issue, we investigated the effects of PSF knockdown in two different colon cancer cell lines, DLD-1 and HT-29. We found that knockdown of PSF markedly decreased the autophagic molecule LC3B in DLD-1 cells but not in HT-29 cells. Furthermore, DLD-1 cells were more susceptible to PSF knockdown-induced cell growth inhibition and apoptosis than HT-29 cells. This susceptibility is probably a result of LC3B inhibition, given the known relationship between autophagy and apoptosis. C3B is associated with a number of physiological processes, including cell growth and apoptotic cell death. Our results suggest that autophagy is inhibited by PSF knockdown and that apoptosis and cell growth inhibition may act together to mediate the PSF-LC3B signaling pathway. Furthermore, we found that the peroxisome proliferator-activated receptor gamma (PPAR gamma)-PSF complex induced LC3B downregulation in DLD-1 cells. The results of this study identify a new physiological role for the PSF-LC3B axis as a potential endogenous modulator of colon cancer treatment. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 2314-6133 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24288667/ | |||||
関連名称 | 24288667 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1155/2013/204973 | |||||
関連名称 | 10.1155/2013/204973 | |||||
権利 | ||||||
権利情報 | Copyright© 2013 Tamotsu Tsukahara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000326788000001 |