@article{oai:soar-ir.repo.nii.ac.jp:00003777, author = {Watanabe, Takayuki and Maruyama, Masahiro and Ito, Tetsuya and Kanai, Keita and Oguchi, Takaya and Muraki, Takashi and Hamano, Hideaki and Arakura, Norikazu and Ota, Masao and Kawa, Shigeyuki}, issue = {8}, journal = {INTERNAL MEDICINE}, month = {Jan}, note = {Type 1 autoimmune pancreatitis (AIP) is characterized by a high serum IgG4 concentration and is closely associated with the HLA-DRB1*04:05-DQB1*04:01 haplotype, for which family studies may disclose its immunogenetic significance. In the present study, we encountered two male siblings with type 1 AIP who exhibited diffuse pancreatic swelling with a capsule-like rim and diffuse pancreatic duct stricture. The younger brother also displayed characteristic IgG4-related sialadenitis and retroperitoneal fibrosis. Contrary to our expectations, the siblings showed only normal or slightly elevated values of serum IgG4 and no HLA DRB1*04:05-DQB1*04:01 haplotype, suggesting that type 1 autoimmune pancreatitis is associated with multiple immunogenetic factors., Article, INTERNAL MEDICINE. 52(8):895-899 (2013)}, pages = {895--899}, title = {Two Siblings with Type 1 Autoimmune Pancreatitis}, volume = {52}, year = {2013} }