@article{oai:soar-ir.repo.nii.ac.jp:00003811,
 author = {Jian,  Ming-Yuan and Koizumi,  Tomonobu and Yokoyama,  Toshiki and Tsushima,  Kenji and Kubo,  Keishi},
 issue = {11},
 journal = {INFLAMMATION RESEARCH},
 month = {Nov},
 note = {The present study was performed to compare the effects of high frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation (CMV) on pulmonary inflammatory responses in a rat acid-induced lung injury model. Anesthetized rats were instilled intratracheally with HCl (0.1 N, 2 mL/kg) and then randomly divided into three mechanical ventilation settings: HFOV (an oscillatory frequency of 15 Hz, mean airway pressure (MAP) of 9 cmH(2)O), CMV at tidal volume of 12 and 6 mL/kg for 5 h. After HCl instillation, HFOV significantly attenuated the increases in neutrophil infiltration and TNF-alpha concentration in bronchoalveolar lavage fluid compared with the CMV groups. During HFOV, there was an inhibition of an increase in TNF-alpha mRNA expression and a decrease in SP-A mRNA expression induced by acid instillation. This animal study demonstrates that HFOV is a suitable form of mechanical ventilation to prevent inflammatory responses in acid-induced lung injury., Article, INFLAMMATION RESEARCH. 59(11):931-937 (2010)},
 pages = {931--937},
 title = {Comparison of acid-induced inflammatory responses in the rat lung during high frequency oscillatory and conventional mechanical ventilation},
 volume = {59},
 year = {2010}
}