{"created":"2021-03-01T06:07:38.908944+00:00","id":3815,"links":{},"metadata":{"_buckets":{"deposit":"06f06a0b-a6b5-4619-a0d7-275c5f9af2ea"},"_deposit":{"id":"3815","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3815"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00003815","sets":["461:462"]},"item_6_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"100","bibliographicPageStart":"91","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"GENES TO CELLS"}]}]},"item_6_description_20":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a member of the nuclear receptor family, regulating fatty acid degradation in many organs. Two-dimensional SDS-PAGE of brown adipose tissue (BAT) from PPAR alpha-null mice produced a higher-density spot. Proteomic analysis indicated that the protein was pyruvate dehydrogenase beta (PDH beta). To observe PDH beta regulation in BAT, the organ was stimulated by long-term cold exposure, and the activities of associated enzymes were investigated. Histological and biochemical analyses of BAT showed a significant decrease in the triglyceride content in wild-type mice and some degree of decrease in PPAR alpha-null mice on cold exposure. Analyses of molecules related to glucose metabolism showed that the expression of PDH beta is under PPAR alpha-specific regulation, and that glucose degradation ability may decrease on cold exposure. In contrast, analyses of molecules related to fatty acid metabolism showed that numerous PPAR alpha/gamma target molecules are induced on cold exposure, and that fatty acid degradation ability in wild-type mice is markedly enhanced and also increases to same degree in PPAR alpha-null mice on cold exposure. Thus, this study proposes novel and multiple roles of PPAR alpha in BAT.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"\u5f15\u7528","attribute_value_mlt":[{"subitem_description":"GENES TO CELLS. 15(2):91-100 (2010)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af","attribute_value_mlt":[{"subitem_link_text":"Nakajima, Takero","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html"},{"subitem_link_text":"Kamijo, Yuji","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274177800001"}]},"item_6_publisher_4":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"WILEY-BLACKWELL PUBLISHING, INC"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"20002497"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=20002497","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1111/j.1365-2443.2009.01368.x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1111/j.1365-2443.2009.01368.x","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"\u6a29\u5229","attribute_value_mlt":[{"subitem_rights":"The definitive version is available at www3.intersience.wiley.com"}]},"item_6_select_64":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"author"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1356-9597","subitem_source_identifier_type":"ISSN"}]},"item_6_source_id_40":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11078945","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Komatsu,  Makiko"}],"nameIdentifiers":[{"nameIdentifier":"7231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tong,  Yuhong"}],"nameIdentifiers":[{"nameIdentifier":"7232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li,  Yufeng"}],"nameIdentifiers":[{"nameIdentifier":"7233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima,  Takero"}],"nameIdentifiers":[{"nameIdentifier":"7234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li,  Gang"}],"nameIdentifiers":[{"nameIdentifier":"7235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hu,  Rui"}],"nameIdentifiers":[{"nameIdentifier":"7236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama,  Eiko"}],"nameIdentifiers":[{"nameIdentifier":"7237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamijo,  Yuji"}],"nameIdentifiers":[{"nameIdentifier":"7238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka,  Naoki"}],"nameIdentifiers":[{"nameIdentifier":"7239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara,  Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"7240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoyama,  Toshifumi"}],"nameIdentifiers":[{"nameIdentifier":"7241","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Multiple_roles_PPAR_alpha_brown_adipose_tissue.pdf","filesize":[{"value":"5.8 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conditions"}]},"item_type_id":"6","owner":"1","path":["461/462"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2013-02-13"},"publish_date":"2013-02-13","publish_status":"0","recid":"3815","relation_version_is_last":true,"title":["Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions"],"weko_creator_id":"1","weko_shared_id":3},"updated":"2021-07-05T00:44:09.202522+00:00"}