@article{oai:soar-ir.repo.nii.ac.jp:00003843,
 author = {Ota,  Hiroyoshi and Harada,  Oi and Uehara,  Takeshi and Hayama,  Masayoshi and Ishii,  Keiko},
 issue = {2},
 journal = {AMERICAN JOURNAL OF CLINICAL PATHOLOGY},
 month = {Feb},
 note = {Lobular endocervical glandular hyperplasia (LEGH) is a distinct benign glandular lesion expressing gastric gland mucous cell-type mucin (N-acetylglucosaminal -> 4galactose -> R [GlcNAc alpha 1 -> 4Gal -> R]). To investigate histogenesis and diagnostic markers of LEGH, we examined the immunohistochemical expression profile of gastric surface mucous cell (MUC5AC and TFF1), gastric gland mucous cell (MUC6, TFF2, and GlcNAc alpha 1 -> 4Gal -> R), gastric pyloric epithelial cell (PDX1), and endocervical cell (keratan sulfate) markers in normal endocervix samples and benign glandular lesions (nabothian cysts, tunnel clusters, and LEGHs). MUC5AC and MUC6 were expressed in normal endocervical mucosa and benign glandular lesions. TFF1, TFF2, GlcNAc alpha 1 -> 4Gal -> R, and PDX1 were expressed only in LEGH. Keratan sulfate was expressed in normal endocervical mucosa and benign glandular lesions. In LEGH, gastric surface mucous cell and gastric gland mucous cell differentiation were demonstrated, and transdifferentiation from endocervical mucosa into gastric pyloric mucosa was suggested. In addition to GlcNAc alpha 1 -> 4Gal -> R, TFF1, TFF2, and PDX1 are additional useful markers for LEGH., Article, AMERICAN JOURNAL OF CLINICAL PATHOLOGY. 135(2):253-261 (2011)},
 pages = {253--261},
 title = {Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia},
 volume = {135},
 year = {2011}
}