{"created":"2021-03-01T06:07:40.584162+00:00","id":3843,"links":{},"metadata":{"_buckets":{"deposit":"2f142feb-3a22-4770-8d5c-1425cdf0b4a0"},"_deposit":{"id":"3843","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3843"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00003843","sets":["461:462"]},"author_link":["7453","7454","7455","7456","7457"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"261","bibliographicPageStart":"253","bibliographicVolumeNumber":"135","bibliographic_titles":[{"bibliographic_title":"AMERICAN JOURNAL OF CLINICAL PATHOLOGY"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lobular endocervical glandular hyperplasia (LEGH) is a distinct benign glandular lesion expressing gastric gland mucous cell-type mucin (N-acetylglucosaminal -> 4galactose -> R [GlcNAc alpha 1 -> 4Gal -> R]). To investigate histogenesis and diagnostic markers of LEGH, we examined the immunohistochemical expression profile of gastric surface mucous cell (MUC5AC and TFF1), gastric gland mucous cell (MUC6, TFF2, and GlcNAc alpha 1 -> 4Gal -> R), gastric pyloric epithelial cell (PDX1), and endocervical cell (keratan sulfate) markers in normal endocervix samples and benign glandular lesions (nabothian cysts, tunnel clusters, and LEGHs). MUC5AC and MUC6 were expressed in normal endocervical mucosa and benign glandular lesions. TFF1, TFF2, GlcNAc alpha 1 -> 4Gal -> R, and PDX1 were expressed only in LEGH. Keratan sulfate was expressed in normal endocervical mucosa and benign glandular lesions. In LEGH, gastric surface mucous cell and gastric gland mucous cell differentiation were demonstrated, and transdifferentiation from endocervical mucosa into gastric pyloric mucosa was suggested. In addition to GlcNAc alpha 1 -> 4Gal -> R, TFF1, TFF2, and PDX1 are additional useful markers for LEGH.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"AMERICAN JOURNAL OF CLINICAL PATHOLOGY. 135(2):253-261 (2011)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Ota, Hiroyoshi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WNkCHhkh.html"},{"subitem_link_text":"Uehara, Takeshi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyegpkh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286452800009"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"AMER SOC CLINICAL PATHOLOGY"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"21228366"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/21228366","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1309/AJCPQMAO3PW4OGOF"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1309/AJCPQMAO3PW4OGOF","subitem_relation_type_select":"DOI"}}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0002-9173","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00520469","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ota,  Hiroyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Harada,  Oi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uehara,  Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayama,  Masayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii,  Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Aberrant_Expression_TFF1_TFF2_PDX1.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Aberrant_Expression_TFF1_TFF2_PDX1.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/3843/files/Aberrant_Expression_TFF1_TFF2_PDX1.pdf"},"version_id":"4bd82d38-1861-4612-a85b-2554f989bee8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Endocervix","subitem_subject_scheme":"Other"},{"subitem_subject":"Human","subitem_subject_scheme":"Other"},{"subitem_subject":"Keratan sulfate","subitem_subject_scheme":"Other"},{"subitem_subject":"Lobular endocervical glandular hyperplasia","subitem_subject_scheme":"Other"},{"subitem_subject":"Mucin","subitem_subject_scheme":"Other"},{"subitem_subject":"Pancreatic-duodenal homeobox 1","subitem_subject_scheme":"Other"},{"subitem_subject":"PDX1","subitem_subject_scheme":"Other"},{"subitem_subject":"Trefoil factor family","subitem_subject_scheme":"Other"},{"subitem_subject":"TFF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-09-21"},"publish_date":"2012-09-21","publish_status":"0","recid":"3843","relation_version_is_last":true,"title":["Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:39:57.198729+00:00"}