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Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1
http://hdl.handle.net/10091/13266
http://hdl.handle.net/10091/132661b623ee7-4f63-4915-8ba4-de245f8d2722
| 名前 / ファイル | ライセンス | アクション |
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Genes_Difference_Eosinophilic_Phenotype.pdf (515.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2011-10-11 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1 | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.1538/expanim.60.151 | |||||||||||||||
| 関連名称 | 10.1538/expanim.60.151 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Cyba, eosinophilia, genetic polymorphism, NADPH oxidase, rat strain | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | journal article | |||||||||||||||
| 著者 |
Tomozawa, Hiroshi
× Tomozawa, Hiroshi
× Nishio, Ayako
× Higuchi, Keiichi
× Matsumoto, Kiyoshi
× Mori, Masayuki
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| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | Higuchi, Keiichi | |||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | Matsumoto, Kiyoshi | |||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yVSNupkh.html | |||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||
| 氏名 | Mori, Masayuki | |||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Japanese Association for Laboratory Animal Science | |||||||||||||||
| 引用 | ||||||||||||||||
| 内容記述 | EXPERIMENTAL ANIMALS. 60(2):151-160 (2011) | |||||||||||||||
| 書誌情報 |
EXPERIMENTAL ANIMALS 巻 60, 号 2, p. 151-160, 発行日 2011-04 |
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| 抄録 | ||||||||||||||||
| 内容記述 | The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia due to the mutant Cyba(mes) gene. In contrast, BN.MES-Cyba(mes) congenic rats, in which the mutant Cyba(mes) gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. However, the congenic rats manifest focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. To elucidate the genetic basis for the strain differences, (MES x BN.MES-Cyba(mes))F(2) rats were bred, and genetic analyses of phenotypes for eosinophilia were performed. Blood and bone marrow eosinophil levels in the F(2) rats showed broad distributions, suggesting that the traits were under the influence of multiple genes. Genetic association studies revealed that BN-derived marker loci on chromosomes 9 and 5 were responsible for the increase in eosinophil level in the bone marrow, decrease in blood eosinophil level, and the induction of focal necrosis with eosinophilic infiltration in the liver. The BN-derived allele of the marker gene on chromosome 1 was responsible for the decrease of both bone marrow and blood eosinophil levels. These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cyba(mes) on these chromosomes, and form the basis for positional cloning studies of the genes. These studies will advance the understanding of the mechanisms involved in eosinophil mobilization from the bone marrow and recruitment to the organs. | |||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 1341-1357 | |||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA11032321 | |||||||||||||||
| PubMed | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21512270 | |||||||||||||||
| 関連名称 | 21512270 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | Copyright (c) 2011 Japanese Association for Laboratory Animal Science | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| WoS | ||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289818300007 | |||||||||||||||
