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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1

http://hdl.handle.net/10091/13266
http://hdl.handle.net/10091/13266
1b623ee7-4f63-4915-8ba4-de245f8d2722
名前 / ファイル ライセンス アクション
Genes_Difference_Eosinophilic_Phenotype.pdf Genes_Difference_Eosinophilic_Phenotype.pdf (515.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-10-11
タイトル
言語 en
タイトル Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1
言語
言語 eng
キーワード
主題Scheme Other
主題 Cyba
キーワード
主題Scheme Other
主題 eosinophilia
キーワード
主題Scheme Other
主題 genetic polymorphism
キーワード
主題Scheme Other
主題 NADPH oxidase
キーワード
主題Scheme Other
主題 rat strain
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tomozawa, Hiroshi

× Tomozawa, Hiroshi

WEKO 7518

en Tomozawa, Hiroshi

Search repository
Nishio, Ayako

× Nishio, Ayako

WEKO 7519

en Nishio, Ayako

Search repository
Higuchi, Keiichi

× Higuchi, Keiichi

WEKO 7520

en Higuchi, Keiichi

Search repository
Matsumoto, Kiyoshi

× Matsumoto, Kiyoshi

WEKO 7521

en Matsumoto, Kiyoshi

Search repository
Mori, Masayuki

× Mori, Masayuki

WEKO 7522

en Mori, Masayuki

Search repository
信州大学研究者総覧へのリンク
氏名 Higuchi, Keiichi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html
信州大学研究者総覧へのリンク
氏名 Matsumoto, Kiyoshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yVSNupkh.html
信州大学研究者総覧へのリンク
氏名 Mori, Masayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html
出版者
出版者 Japanese Association for Laboratory Animal Science
引用
内容記述タイプ Other
内容記述 EXPERIMENTAL ANIMALS. 60(2):151-160 (2011)
書誌情報 EXPERIMENTAL ANIMALS

巻 60, 号 2, p. 151-160, 発行日 2011-04
抄録
内容記述タイプ Abstract
内容記述 The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia due to the mutant Cyba(mes) gene. In contrast, BN.MES-Cyba(mes) congenic rats, in which the mutant Cyba(mes) gene introduced into the background of the BN strain, have a normal blood eosinophil level despite showing robust proliferation of eosinophils in the bone marrow. However, the congenic rats manifest focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. To elucidate the genetic basis for the strain differences, (MES x BN.MES-Cyba(mes))F(2) rats were bred, and genetic analyses of phenotypes for eosinophilia were performed. Blood and bone marrow eosinophil levels in the F(2) rats showed broad distributions, suggesting that the traits were under the influence of multiple genes. Genetic association studies revealed that BN-derived marker loci on chromosomes 9 and 5 were responsible for the increase in eosinophil level in the bone marrow, decrease in blood eosinophil level, and the induction of focal necrosis with eosinophilic infiltration in the liver. The BN-derived allele of the marker gene on chromosome 1 was responsible for the decrease of both bone marrow and blood eosinophil levels. These data suggest the existence of genes characterizing/distinguishing the eosinophilic phenotypes of MES and BN.MES-Cyba(mes) on these chromosomes, and form the basis for positional cloning studies of the genes. These studies will advance the understanding of the mechanisms involved in eosinophil mobilization from the bone marrow and recruitment to the organs.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1341-1357
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11032321
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21512270
関連名称 21512270
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1538/expanim.60.151
関連名称 10.1538/expanim.60.151
権利
権利情報 Copyright (c) 2011 Japanese Association for Laboratory Animal Science
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000289818300007
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