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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients

http://hdl.handle.net/10091/11112
4ac2d534-4122-40b4-97d9-fc5d46ad292e
名前 / ファイル ライセンス アクション
Association_Analysis_Cytotoxic_T-lymphocyte_Antigen.pdf Association_Analysis_Cytotoxic_T-lymphocyte_Antigen.pdf (304.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-26
タイトル
言語 en
タイトル Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients
言語
言語 eng
キーワード
主題Scheme Other
主題 Primary biliary cirrhosis
キーワード
主題Scheme Other
主題 Single nucleotide polymorphisms
キーワード
主題Scheme Other
主題 Cytotoxic T-lymphocyte antigen 4
キーワード
主題Scheme Other
主題 Genetic susceptibility
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Joshita, Satoru

× Joshita, Satoru

WEKO 7558

en Joshita, Satoru

Search repository
Umemura, Takeji

× Umemura, Takeji

WEKO 7559

en Umemura, Takeji

Search repository
Yoshizawa, Kaname

× Yoshizawa, Kaname

WEKO 7560

en Yoshizawa, Kaname

Search repository
Katsuyama, Yoshihiko

× Katsuyama, Yoshihiko

WEKO 7561

en Katsuyama, Yoshihiko

Search repository
Tanaka, Eiji

× Tanaka, Eiji

WEKO 7562

en Tanaka, Eiji

Search repository
Nakamura, Minoru

× Nakamura, Minoru

WEKO 7563

en Nakamura, Minoru

Search repository
Ishibashi, Hiromi

× Ishibashi, Hiromi

WEKO 7564

en Ishibashi, Hiromi

Search repository
Ota, Masao

× Ota, Masao

WEKO 7565

en Ota, Masao

Search repository
信州大学研究者総覧へのリンク
氏名 Joshita, Satoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.PeLNbVym.html
信州大学研究者総覧へのリンク
氏名 Umemura, Takeji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
信州大学研究者総覧へのリンク
氏名 Tanaka, Eiji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
信州大学研究者総覧へのリンク
氏名 Ota, Masao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
出版者
出版者 ELSEVIER SCIENCE BV
引用
内容記述タイプ Other
内容記述 JOURNAL OF HEPATOLOGY. 53(3):537-541 (2010)
書誌情報 en : JOURNAL OF HEPATOLOGY

巻 53, 号 3, p. 537-541, 発行日 2010-09
抄録
内容記述タイプ Abstract
内容記述 Background & Aims: Primary biliary cirrhosis (PBC) is an organ-specific autoimmune disease of still unidentified genetic etiology that is characterized by chronic inflammation of the liver. Since cytotoxic T-lymphocyte antigen 4 (CTLA4) polymorphisms have recently been linked with PBC susceptibility in studies on Caucasians, we investigated the genetic association between CTLA4 polymorphisms and PBC in a Japanese population. Methods: Five single nucleotide polymorphisms (SNPs) in the CTLA4 gene (rs733618, rs5742909, rs231775, rs3087243, and rs231725) were genotyped in 308 patients with PBC and 268 healthy controls using a TaqMan assay. Results: One CTLA4 gene SNP (rs231725) was significantly associated with susceptibility to anti-mitochondrial antibody (AMA)-positive PBC, but clinical significance disappeared after correction for multiple testing. Moreover, CTLA4 gene SNPs did not influence AMA development or disease progression to orthotopic liver transplantation in our Japanese cohort. In haplotype analyses, one haplotype [haplotype 1 (CGGA)] at rs5742909, rs231775, rs3087243, and rs231725, was significantly associated with susceptibility to both AMA-positive PBC and overall PBC. Conclusions: This study showed that CTLA4 gene polymorphisms had a modest, but significant association with susceptibility to PBC in the Japanese population. The connection between genetic variants and the function of the CTLA4 gene remains to be addressed in future investigations.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0168-8278
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10459105
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20557968
関連名称
関連名称 20557968
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jhep.2010.03.017
関連名称
関連名称 10.1016/j.jhep.2010.03.017
権利
権利情報 Copyright (c) 2010 European Association for the Study of the Liver Published by Elsevier Ireland Ltd.
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000281985900019
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