@article{oai:soar-ir.repo.nii.ac.jp:00003868,
 author = {Yanagisawa,  Ryu and Nakazawa,  Yozo and Sakashita,  Kazuo and Tanaka,  Miyuki and Shikama,  Naoto and Kamijo,  Takehiko and Shiohara,  Masaaki and Koike,  Kenichi},
 issue = {6},
 journal = {PEDIATRIC TRANSPLANTATION},
 month = {Sep},
 note = {The definitive version is available at www.blackwell-synergy.com, We here report the efficacy and toxicity of a conditioning regimen with fractionated 8-Gy TBI, fludarabine, and cyclophosphamide in allogeneic HSCT for pediatric hematological malignancies. Among 22 children who received related or unrelated HSCT, nine were transplanted with refractory disease and/or from HLA two or more loci-mismatched family donors. None of the patients developed graft failure. The Seattle grading system revealed that 18 patients had no RRT, and the remaining patients had grade I gastrointestinal toxicity alone. The estimated overall survival and leukemia-free survival at two yr were 57.1% and 48.0%, respectively, in 10 patients with acute lymphoblastic leukemia; 91.7% and 71.3%, respectively, in 12 patients with myeloid leukemia. The incidence of TRM was 4.8% at two yr. The rates of RRT above grade II and TRM in an 8-Gy TBI-containing regimen were significantly lower than the data of historical control patients who underwent 12-Gy TBI and cyclophosphamide with or without etoposide. The intermediate-dose TBI-based conditioning regimen may confer successful engraftment combined with minimized RRT, although its efficacy should be further evaluated., Article, PEDIATRIC TRANSPLANTATION. 13(6):737-745 (2009)},
 pages = {737--745},
 title = {Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies},
 volume = {13},
 year = {2009}
}