@article{oai:soar-ir.repo.nii.ac.jp:00003869,
 author = {Ono,  Koichi and Koizumi,  Tomonobu and Tsushima,  Kenji and Yoshikawa,  Sumiko and Yokoyama,  Toshiki and Nakagawa,  Rikimaru and Obata,  Toru},
 issue = {2},
 journal = {BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS},
 month = {Oct},
 note = {The present study was performed to examine a role of oxidative stress in oleic acid-induced lung injury model. Fifteen anesthetized sheep were ventilated and instrumented with a lung lymph fistula and vascular catheters for blood gas analysis and measurement of isoprostanes (8-epi prostaglandin F2 alpha). Following stable baseline measurements, oleic acid (0.08 ml/kg) was administered and observed 4 h. Isoprostane was measured by gas chromatography mass spectrometry with the isotope dilution method. Isoprostane levels in plasma and lung lymph were significantly increased 2 h after oleic acid administration and then decreased at 4 h. The percent increases in isoprostane levels in plasma and lung lymph at 2 h were significantly correlated with deteriorated oxygenation at the same time point, respectively. These findings suggest that oxidative stress is involved in the pathogenesis of the pulmonary fat embolism-induced acute lung injury model in sheep and that the increase relates with the deteriorated oxygenation., Article, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 388(2):297-300 (2009)},
 pages = {297--300},
 title = {Increased isoprostane levels in oleic acid-induced lung injury},
 volume = {388},
 year = {2009}
}