@article{oai:soar-ir.repo.nii.ac.jp:00003883, author = {Joshita, Satoru and Nakazawa, Koh and Sugiyama, Yukiko and Kamijo, Atsushi and Matsubayashi, Kiyoshi and Miyabayashi, Hideharu and Furuta, Kiyoshi and Kitano, Kiyoshi and Kawa, Shigeyuki}, issue = {9}, journal = {INTERNAL MEDICINE}, month = {}, note = {Herein, we encountered an 89-year-old woman with pancreatic cancer who presented with fever without infective focus, leukocytosis of 45,860/mu L, and elevation of serum granulocyte-colony stimulating factor (G-CSF). The patient could not receive any curative therapy due to an extremely aggressive clinical course. Specimens taken at necropsy revealed an adenosquamous carcinoma positive for G-CSF by immunohistochemistry; it was only the second reported case to date. She was finally diagnosed with G-CSF-producing pancreatic cancer. In light of the above, clinicians should consider the presence of G-CSF-producing tumors, including pancreatic cancer, when presented with patients showing leukocytosis of unknown origin and fever without infective focus., Article, INTERNAL MEDICINE. 48(9):687-691 (2009)}, pages = {687--691}, title = {Granulocyte-Colony Stimulating Factor-Producing Pancreatic Adenosquamous Carcinoma Showing Aggressive Clinical Course}, volume = {48}, year = {2009} }