@article{oai:soar-ir.repo.nii.ac.jp:00003896, author = {Katoh, Nagaaki and Matsuda, Masayuki and Ishii, Wataru and Morita, Hiroshi and Ikeda, Shu-ichi}, issue = {3}, journal = {INTERNAL MEDICINE}, month = {}, note = {We report a patient with stiff-person syndrome and insulin-dependent diabetes mellitus with anti-glutamic acid decarboxylase (GAD) antibody, who suddenly complained of diplopia due to dysthyroid ophthalmopathy. Therapeutic efficacy of plasmapheresis and high-dose intravenous immunoglobulin was transient. After starting administration of rituximab, the patient showed obvious improvement of muscle spasms due to stiff-person syndrome and ophthalmoplegia following quick depletion of CD20-positive cells in peripheral blood. The anti-GAD and anti-thyroid antibodies decreased slowly. This drug might be a potent therapeutic option for refractory patients with stiff-person syndrome, particularly in those associated with dysthyroid ophthalmopathy., Article, INTERNAL MEDICINE. 49(3):237-241 (2010)}, pages = {237--241}, title = {Successful Treatment with Rituximab in a Patient with Stiff-Person Syndrome Complicated by Dysthyroid Ophthalmopathy}, volume = {49}, year = {2010} }