{"created":"2021-03-01T06:07:44.420554+00:00","id":3907,"links":{},"metadata":{"_buckets":{"deposit":"ebb0a13c-f311-4db0-a218-91795b857f8a"},"_deposit":{"id":"3907","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3907"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00003907","sets":["461:462"]},"author_link":["7905","7906","7907","7908","7909","7910","7911","7912","7913","7914","7915","7916","7917"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"871","bibliographicPageStart":"865","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"PEPTIDES"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Donor organ damage caused by cold preservation is a major problem affecting liver transplantation. Cold preservation most easily damages liver sinusoidal endothelial cells (LSECs), and information about the molecules modulating LSECs function can provide the basis for new therapeutic strategies. Adrenomedullin (AM) is a peptide known to possess anti-apoptotic and anti-inflammatory properties. AM is abundant in vascular endothelial cells, but levels are comparatively low in liver, and little is known about its function there. In this study, we demonstrated both AM and its receptors are expressed in LSECs. AM treatment reduced LSECs loss and apoptosis under cold treatment. AM also downregulated cold-induced expression of TNF alpha, IL1 beta, IL6, ICAM1 and VCAM1. AM reduced apoptosis and expression of ICAM1 and VCAM1 in an in vivo liver model subjected to cold storage. Conversely, apoptosis was exacerbated in livers from AM and RAMP2 (AM receptor activity-modifying protein) knockout mice. These results suggest that AM expressed in LSECs exerts a protective effect against cold-organ damage through modulation of apoptosis and inflammation.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PEPTIDES. 31(5):865-871 (2010)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Sakurai, Takayuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.jaLUuNkh.html"},{"subitem_link_text":"Kamiyoshi, Akiko","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OpLVuNkh.html"},{"subitem_link_text":"Shindo, Takayuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OCLpOayV.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000277768400010"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER SCIENCE INC"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"20132855"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/20132855","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.peptides.2010.01.011"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.peptides.2010.01.011","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2010 Elsevier Inc."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0196-9781","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10617807","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Iinuma,  Nobuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakurai,  Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamiyoshi,  Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichikawa-Shindo,  Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arai,  Takuma","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizawa,  Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koyama,  Teruhide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uetake,  Ryuichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawate,  Hisaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Muto,  Shin-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tagawa,  Yoh-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyagawa,  Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shindo,  Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Adrenomedullin_sinusoidal_endothelial_cells.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Adrenomedullin_sinusoidal_endothelial_cells.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/3907/files/Adrenomedullin_sinusoidal_endothelial_cells.pdf"},"version_id":"66c2125f-20c2-480f-ac15-adcade9be238"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adrenomedullin (AM)","subitem_subject_scheme":"Other"},{"subitem_subject":"Receptor activity-modifying protein (RAMP)","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver sinusoidal endothelial cell (LSEC)","subitem_subject_scheme":"Other"},{"subitem_subject":"Vasoactive peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver","subitem_subject_scheme":"Other"},{"subitem_subject":"Cold injury","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-12-02"},"publish_date":"2010-12-02","publish_status":"0","recid":"3907","relation_version_is_last":true,"title":["Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:20:13.239730+00:00"}