{"created":"2021-03-01T06:07:44.777674+00:00","id":3913,"links":{},"metadata":{"_buckets":{"deposit":"5828bbd1-31cd-4d2d-9b84-0e33ed7d9f8a"},"_deposit":{"id":"3913","owners":[],"pid":{"revision_id":0,"type":"depid","value":"3913"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00003913","sets":["461:462"]},"author_link":["7950","7951","7952","7953","7954","7955","7956","7957","7958"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1529","bibliographicPageStart":"1517","bibliographicVolumeNumber":"1794","bibliographic_titles":[{"bibliographic_title":"BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In mice, amyloidogenic type C apolipoprotein A-II (apoA-II) forms amyloid fibrils in age-associated amyloidosis. To understand the mechanism of amyloid fibril formation by apoA-II, we examined the polymerization of synthetic partial peptides of apoA-II in vitro. None of the partial apoA-II peptides polymerized into amyloid fibrils when tested as a single species mixture. We found a unique mechanism in which N- and C-terminal peptides associated into amyloid fibrils in a 1:1 ratio at pH 2.5. The 11-residue amino acid sequence (6-16), which is a common sequence of type B apoA-II and type C apoA-II proteins in amyloidosis-resistant mice and amyloidosis-susceptible mice, respectively, was critical for polymerization into amyloid fibrils. The 18-residue-long amino acid sequence (48-65) is also necessary for nucleation, but not for the extension phase. These findings suggest that there may be different mechanisms underlying the nucleation and extension phases of apoA-II amyloid fibril formation. We also found that amino acid substitutions between type B apoA-II (Pro5, Val38) and type C apoA-II (Gln5, Ala38) did not affect either phase. The strategy of using synthetic partial peptides of amyloidogenic proteins in vitro is a useful system for understanding amyloid fibril formation and for the development of novel therapies.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 1794(10):1517-1529 (2009)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"Mori, Masayuki","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html"},{"subitem_link_text":"Higuchi, Keiichi","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html"}]},"item_6_link_67":{"attribute_name":"WoS","attribute_value_mlt":[{"subitem_link_text":"Web of Science","subitem_link_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270259000017"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER SCIENCE BV"}]},"item_6_relation_47":{"attribute_name":"PubMed","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"19596087"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubmed.ncbi.nlm.nih.gov/19596087","subitem_relation_type_select":"PMID"}}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.bbapap.2009.06.028"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbapap.2009.06.028","subitem_relation_type_select":"DOI"}}]},"item_6_rights_62":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2009 Elsevier B.V."}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1570-9639","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11685085","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sawashita,  Jinko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kametani,  Fuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa,  Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsutsumi-Yasuhara,  Shinobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang,  Beiru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan,  Jingmin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori,  Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naiki,  Hironobu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi,  Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7958","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Amyloid_fibrils_formed_selective_N-C-terminal.pdf","filesize":[{"value":"901.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Amyloid_fibrils_formed_selective_N-C-terminal.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/3913/files/Amyloid_fibrils_formed_selective_N-C-terminal.pdf"},"version_id":"55c2c40a-9225-4513-bf4d-8c6c619d1fb5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Apolipoprotein A-II","subitem_subject_scheme":"Other"},{"subitem_subject":"Mouse senile amyloidosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibril conformation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["462"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-11-18"},"publish_date":"2010-11-18","publish_status":"0","recid":"3913","relation_version_is_last":true,"title":["Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T04:40:28.017747+00:00"}