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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress

http://hdl.handle.net/10091/3107
02ee687c-bc15-4016-b111-d64cd3767bd0
名前 / ファイル ライセンス アクション
JHE-2008-1619-R1.pdf JHE-2008-1619-R1.pdf (146.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-06-18
タイトル
言語 en
タイトル Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Okiyama, W

× Okiyama, W

WEKO 8121

en Okiyama, W

Search repository
Tanaka, N

× Tanaka, N

WEKO 8122

en Tanaka, N

Search repository
Nakajima, T

× Nakajima, T

WEKO 8123

en Nakajima, T

Search repository
Tanaka, E

× Tanaka, E

WEKO 8124

en Tanaka, E

Search repository
Kiyosawa, K

× Kiyosawa, K

WEKO 8125

en Kiyosawa, K

Search repository
Gonzalez, FJ

× Gonzalez, FJ

WEKO 8126

en Gonzalez, FJ

Search repository
Aoyama, T

× Aoyama, T

WEKO 8127

en Aoyama, T

Search repository
信州大学研究者総覧へのリンク
氏名 Tanaka, E
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html
出版者
出版者 Elsevier Science B.V.
引用
内容記述タイプ Other
内容記述 Journal of Hepatology 50(6): 1236-1246(2009)
書誌情報 Journal of Hepatology

巻 50, 号 6, p. 1236-1246, 発行日 2009-06
抄録
内容記述タイプ Abstract
内容記述 Background/Aims: Alcoholic liver disease (ALD) is one of the leading causes of cirrhosis and yet efficient therapeutic strategies are lacking. Polyenephosphatidylcholine (PPC), a major component of essential phospholipids, prevented alcoholic liver fibrosis in baboons, but its precise mechanism remains uncertain. We aimed to explore the effects of PPC on ALD using ethanol-fed peroxisome proliferator-activated receptor α (Ppara)-null mice, showing several similarities to human ALD. Methods: Male wild-type and Ppara-null mice were pair-fed a Lieber-DeCarli control or 4% ethanol-containing diet with or without PPC (30 mg/kg/day) for 6 months. Results: PPC significantly ameliorated ethanol-induced hepatocyte damage and hepatitis in Ppara-null mice. These effects were likely a consequence of decreased oxidative stress through down-regulation of reactive oxygen species (ROS)-generating enzymes, including cytochrome P450 2E1, acyl-CoA oxidase, and NADPH oxidases, in addition to restoration of increases in Toll-like receptor 4 and CD14. PPC also decreased Bax and truncated Bid, thus inhibiting apoptosis. Furthermore, PPC suppressed increases in transforming growth factor-β1 expression and hepatic stellate cell activation, which retarded hepatic fibrogenesis. Conclusions: PPC exhibited anti-inflammatory, anti-apoptotic, and anti-fibrotic effects on ALD as a result of inhibition of the overexpression of ROS-generating enzymes. Our results demonstrate detailed molecular mechanisms of the anti-oxidant action of PPC.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0168-8278
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10459105
他の資源との関係:URI
関連識別子
識別子タイプ URI
関連識別子 http://www.elsevier.com/wps/find/journaldescription.cws_home/621507/description
関連名称
関連名称 http://www.elsevier.com/wps/find/journaldescription.cws_home/621507/description
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19398233
関連名称
関連名称 19398233
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jhep.2009.01.025
関連名称
関連名称 10.1016/j.jhep.2009.01.025
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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