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They adapt to high altitude so well that little acute or chronic mountain sickness has been documented in them. The possible genetic basis for this adaptation is, however, unclear. The objective of this study was to elucidate the genetic background underlying this characteristic among Sherpas with respect to the angiotension-converting enzyme (ACE) gene. Methods.-We enrolled 105 Sherpa volunteers in Namche Bazaar (3440 meters) and 111 non-Sherpa Nepalese volunteers in Kathmandu Valley (1330 meters) in Nepal. Information about high-altitude exposure and physiological phenotypes was obtained via fieldwork investigation. The genotype of the insertion/deletion (I/D) polymorphism in the ACE gene was identified by polymerase chain reaction. Serum ACE activity was also measured. Results.-The distribution of the I dominant genotype (II \u0026 ID) and the I allelic frequency were significantly more prevalent in Sherpas (II \u0026 ID: 94.3%, I allele: 73.3%) than in non-Sherpas (II \u0026 ID: 85.6%, P =.035; I allele: 64.0%, P =.036). Moreover, despite residing at high altitude, the circulating ACE levels of Sherpas were statistically similar to those of non-Sherpas at low altitudes (Sherpas: 14.5 +/- 0.4 IU/L/37 degrees C; non-Sherpas: 14.7 +/- 0.4 IU/L/37 degrees C; P =.755). Conclusions.-These findings suggest that the overrepresented I allele of the ACE gene in Sherpas might be one of the fundamental genetic factors responsible for maintaining physiological low-altitude ACE activity at high altitude, which may have an advantageous physiological role in adapting to a high-altitude environment."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Droma, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanaoka, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Basnyat, B", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arjyal, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8394", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Neupane, P", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Pandit, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sharma, D", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8397", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsuyama, Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota, M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8401", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8402", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "MS-06-WEME-OR-073-R2.pdf", "filesize": [{"value": "170.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 170700.0, "url": {"label": "MS-06-WEME-OR-073-R2.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3978/files/MS-06-WEME-OR-073-R2.pdf"}, "version_id": "9db6d29c-b46c-429d-b2a7-8330165daab6"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/1095", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-06-26"}, "publish_date": "2008-06-26", "publish_status": "0", "recid": "3978", "relation": {}, "relation_version_is_last": true, "title": ["Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene"], "weko_shared_id": -1}
Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene
http://hdl.handle.net/10091/1095
http://hdl.handle.net/10091/10950aee3732-23d8-4d07-94e7-9e3a469469f6
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-06-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Droma, Y
× Droma, Y× Hanaoka, M× Basnyat, B× Arjyal, A× Neupane, P× Pandit, A× Sharma, D× Ito, M× Miwa, N× Katsuyama, Y× Ota, M× Kubo, K |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Hanaoka, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, M | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html | |||||
出版者 | ||||||
出版者 | ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | WILDERNESS & ENVIRONMENTAL MEDICINE. 19(1): 22-29 (2008) | |||||
書誌情報 |
WILDERNESS & ENVIRONMENTAL MEDICINE 巻 19, 号 1, p. 22-29, 発行日 2008 |
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資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1080-6032 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11036672 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1580/06-WEME-OR-073.1 | |||||
関連名称 | 10.1580/06-WEME-OR-073.1 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000254367000005 |