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They adapt to high altitude so well that little acute or chronic mountain sickness has been documented in them. The possible genetic basis for this adaptation is, however, unclear. The objective of this study was to elucidate the genetic background underlying this characteristic among Sherpas with respect to the angiotension-converting enzyme (ACE) gene. Methods.-We enrolled 105 Sherpa volunteers in Namche Bazaar (3440 meters) and 111 non-Sherpa Nepalese volunteers in Kathmandu Valley (1330 meters) in Nepal. Information about high-altitude exposure and physiological phenotypes was obtained via fieldwork investigation. The genotype of the insertion/deletion (I/D) polymorphism in the ACE gene was identified by polymerase chain reaction. Serum ACE activity was also measured. Results.-The distribution of the I dominant genotype (II \u0026 ID) and the I allelic frequency were significantly more prevalent in Sherpas (II \u0026 ID: 94.3%, I allele: 73.3%) than in non-Sherpas (II \u0026 ID: 85.6%, P =.035; I allele: 64.0%, P =.036). Moreover, despite residing at high altitude, the circulating ACE levels of Sherpas were statistically similar to those of non-Sherpas at low altitudes (Sherpas: 14.5 +/- 0.4 IU/L/37 degrees C; non-Sherpas: 14.7 +/- 0.4 IU/L/37 degrees C; P =.755). Conclusions.-These findings suggest that the overrepresented I allele of the ACE gene in Sherpas might be one of the fundamental genetic factors responsible for maintaining physiological low-altitude ACE activity at high altitude, which may have an advantageous physiological role in adapting to a high-altitude environment."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Droma,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanaoka,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Basnyat,  B", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arjyal,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8394", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Neupane,  P", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Pandit,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sharma,  D", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8397", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miwa,  N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsuyama,  Y", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  M", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8401", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubo,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8402", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "MS-06-WEME-OR-073-R2.pdf", "filesize": [{"value": "170.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 170700.0, "url": {"label": "MS-06-WEME-OR-073-R2.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3978/files/MS-06-WEME-OR-073-R2.pdf"}, "version_id": "9db6d29c-b46c-429d-b2a7-8330165daab6"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/1095", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-06-26"}, "publish_date": "2008-06-26", "publish_status": "0", "recid": "3978", "relation": {}, "relation_version_is_last": true, "title": ["Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene

http://hdl.handle.net/10091/1095
0aee3732-23d8-4d07-94e7-9e3a469469f6
名前 / ファイル ライセンス アクション
MS-06-WEME-OR-073-R2.pdf MS-06-WEME-OR-073-R2.pdf (170.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-06-26
タイトル
言語 en
タイトル Adaptation with the to high altitude in sherpas: Association insertion/deletion polymorphism in the angiotensin-converting enzyme gene
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Droma, Y

× Droma, Y

WEKO 8391

en Droma, Y

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Hanaoka, M

× Hanaoka, M

WEKO 8392

en Hanaoka, M

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Basnyat, B

× Basnyat, B

WEKO 8393

en Basnyat, B

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Arjyal, A

× Arjyal, A

WEKO 8394

en Arjyal, A

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Neupane, P

× Neupane, P

WEKO 8395

en Neupane, P

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Pandit, A

× Pandit, A

WEKO 8396

en Pandit, A

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Sharma, D

× Sharma, D

WEKO 8397

en Sharma, D

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Ito, M

× Ito, M

WEKO 8398

en Ito, M

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Miwa, N

× Miwa, N

WEKO 8399

en Miwa, N

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Katsuyama, Y

× Katsuyama, Y

WEKO 8400

en Katsuyama, Y

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Ota, M

× Ota, M

WEKO 8401

en Ota, M

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Kubo, K

× Kubo, K

WEKO 8402

en Kubo, K

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信州大学研究者総覧へのリンク
氏名 Hanaoka, M
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yCLmHVkh.html
信州大学研究者総覧へのリンク
氏名 Ota, M
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html
出版者
出版者 ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS
引用
内容記述タイプ Other
内容記述 WILDERNESS & ENVIRONMENTAL MEDICINE. 19(1): 22-29 (2008)
書誌情報 WILDERNESS & ENVIRONMENTAL MEDICINE

巻 19, 号 1, p. 22-29, 発行日 2008
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1080-6032
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11036672
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1580/06-WEME-OR-073.1
関連名称
関連名称 10.1580/06-WEME-OR-073.1
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000254367000005
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