{"_buckets": {"deposit": "941352d2-e674-4983-a15b-486c8763999b"}, "_deposit": {"id": "4026", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4026"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004026", "sets": ["462"]}, "author_link": ["8685", "8686", "8687", "8688", "8689", "8690", "8691", "8692"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "54", "bibliographicPageStart": "48", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "Journal of viral hepatitis"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "The definitive version is available at www.blackwell-synergy.com", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF VIRAL HEPATITIS. 14(1): 48-54 (2007)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Tanaka, E", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.HFDCHekh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000243008100007"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "BLACKWELL PUBLISHING"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1111/j.1365-2893.2006.00770.x"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/j.1365-2893.2006.00770.x", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1352-0504", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1352-0504", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11054197", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Helicobacter pylori; hepatitis C virus; interferon; ribavirin; thrombocytopenia"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "SEN VIRUS-INFECTION; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; IMMUNE THROMBOCYTOPENIC PURPURA; NON-B-HEPATITIS; HEPATOCELLULAR-CARCINOMA; A VIRUS; INITIAL TREATMENT; RANDOMIZED-TRIAL; CIRRHOSIS; LIVER"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "We sought to clarify the incidence and role of Helicobacter pylori (H. pylori) seropositivity in patients with hepatitis C virus (HCV) infection and the effect of coinfection on interferon-alpha and ribavirin therapy. The presence of H. pylori was tested using a commercially available enzyme immunoassay in serum samples from 93 patients with chronic hepatitis C. Clinical features, HCV markers and response of HCV to interferon-alpha and ribavirin were compared between H. pylori-positive and H. pylori-negative patients. Anti-H. pylori antibody was detected in 45 (48%) of the 93 patients, whose median HCV-RNA level (495 vs 760 kIU/mL; P = 0.013) and platelet count (128 vs 158 x 10(3)/mu L; P = 0.009) were significantly lower than in patients with HCV infection alone. Anti-H. pylori antibody levels were found to be significantly correlated with fibrosis score (P = 0.0083, r = 0.33) but inversely related to platelet count (P = 0.0037, r = -0.34). The sustained response rate for HCV clearance following interferon-alpha and ribavirin treatment did not differ between patients with and without anti-H. pylori seropositivity. The presence of H. pylori [odds ratio (OR) 8.61; 95% confidence interval (CI) 1.59-46.70] and fibrosis score (OR 30.13; 95% CI 5.44-166.78) were found by multivariate analysis to be associated with the decrease of platelet count during therapy. Coexistent H. pylori infection does not demonstrably influence the clinical course of chronic hepatitis C. A possible connection between H. pylori coinfection and thrombocytopenia was found during the treatment course, suggesting that preemptive eradication of H. pylori may facilitate completion of treatment and increased sustained virological response."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Umemura,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Muto,  H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8686", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  E", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8687", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto,  A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichijo,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8689", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshizawa,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8690", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akamatsu,  T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kiyosawa,  K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8692", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JVH_353_2005.R2.pdf", "filesize": [{"value": "298.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 298600.0, "url": {"label": "JVH_353_2005.R2.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4026/files/JVH_353_2005.R2.pdf"}, "version_id": "1c6ea891-142f-4970-be66-adb6b221abca"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Anti-Helicobacter pylori seropositivity: influence on severity and treatment response in patients with chronic hepatitis C", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Anti-Helicobacter pylori seropositivity: influence on severity and treatment response in patients with chronic hepatitis C", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/412", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2007-11-01"}, "publish_date": "2007-11-01", "publish_status": "0", "recid": "4026", "relation": {}, "relation_version_is_last": true, "title": ["Anti-Helicobacter pylori seropositivity: influence on severity and treatment response in patients with chronic hepatitis C"], "weko_shared_id": -1}