{"created":"2021-03-01T06:08:00.800667+00:00","id":4181,"links":{},"metadata":{"_buckets":{"deposit":"531ee54f-03b5-4963-ad87-c202fc9f4a81"},"_deposit":{"id":"4181","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4181"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00004181","sets":["461:463:464:496"]},"author_link":["9510","9511","9512","9513"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"114","bibliographicPageStart":"103","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"信州医学雑誌"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background :To clarify the mechanisms of lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH), we investigated the expression of α1-adrenergic receptor (AR) subtypes and the angiotensin II type 1 receptor (AT1) within the prostate of spontaneously hypertensive rats (SHRs). Methods :Twelve male 25-week-old SHRs and Wistar Kyoto (WKY) rats were randomly separated into two groups (n =6 each). One group was given 20 ml 0.9% sodium chloride solution (saline) orally per kg-body weight daily for one week. The other group received no treatment. After 7 days of saline loading, systolic blood pressure (SBP) and prostate weight were measured. The prostates were immunohistochemically analyzed for α1-AR subtypes and AT1. Results :After 7 days, the SBP and prostate weight of saline-loaded SHRs tended to increase, but was not significantly different compared to the untreated rats.The expression ofα1-AR subtypes and AT1 within the prostates of saline-loaded SHRs was higher than in the untreated ones. In contrast, the expression in the saline-loaded WKY rat prostates did not increase compared to the untreated ones. Conclusion : Increased numbers of α1-AR subtypes and AT1 in saline-loaded SHR prostates might play important roles in the development of LUTS associated with BPH.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"信州医学雑誌. 58(3): 103-114 (2010)","subitem_description_type":"Other"}]},"item_6_link_3":{"attribute_name":"信州大学研究者総覧へのリンク","attribute_value_mlt":[{"subitem_link_text":"ISHIZUKA, Osamu","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html"},{"subitem_link_text":"NISHIZAWA, Osamu","subitem_link_url":"http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州医学会"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.11441/shinshumedj.58.103"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11441/shinshumedj.58.103","subitem_relation_type_select":"DOI"}}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0037-3826","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00120815","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAYAMA, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAMURA, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ISHIZUKA, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIZAWA, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Shinshu_Med58-3-03.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shinshu_Med58-3-03.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/4181/files/Shinshu_Med58-3-03.pdf"},"version_id":"deb0745f-d4dc-447c-b906-3764904894b6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human lung fibroblast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemotaxis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-8","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MCP-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["496"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-06-23"},"publish_date":"2010-06-23","publish_status":"0","recid":"4181","relation_version_is_last":true,"title":["Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-03-06T01:24:23.231311+00:00"}