{"_buckets": {"deposit": "809d96a2-d32a-47e6-8a09-43db42b779a5"}, "_deposit": {"id": "4341", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4341"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004341", "sets": []}, "author_link": ["10159", "10160", "10161", "10162", "10163", "10164", "10165", "10166"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "83", "bibliographicPageStart": "79", "bibliographicVolumeNumber": "49", "bibliographic_titles": [{"bibliographic_title": "信州医学雑誌"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The expression of thymidine phosphorylase (dThd Pase) in node-negative human invasive ductal carcinoma tissues was investigated by the immunocytochemical method using anti-thymidine phosphorylase monoclonal antibody.Subjects were 5 recurrent and 30 non-recurrent patients who underwent surgery at the Department of Surgery at Shinshu University Hospital between 1993 and 1996.The median follow-up period was 62.5 months.Positive dThd Pase staining was observed in the five recurrent and four non-recurrent cases. Tumor recurrence was significantly more developed in patients with dThd Pase positive staining than in those with negative staining (p＜0.01).Among the nine dThd Pase positive cases,four patients who were administered doxifluridine (5’-DFUR) or medroxyprogesterone (MPA) did not manifest recurrence. Among the recurrent patients, two were cured by oral administration of 5’-DFUR or MPA. It is suggested that the expression of thymidine phosphorylase in human breast cancer tissues may be a risk factor for tumor recurrence. The prognosis of node-negative and dThd Pase positive breast cancer patients might be improved by hormonal therapy or oral administration of 5’-DFUR.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "信州医学雑誌 49(2): 79-83(2001)", "subitem_description_type": "Other"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州医学会"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0037-3826", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0037-3826", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00120815", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_66": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "03"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "本原,  昭子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10159", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "麻沼,  和彦", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10160", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤森,  実", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10161", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "土屋,  眞一", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10162", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "浜,  善久", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10163", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丸山,  正幸", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10164", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "草間,  律", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10165", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "天野,  純", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10166", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Shinshu_Med49-2-03.pdf", "filesize": [{"value": "314.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 314100.0, "url": {"label": "Shinshu_Med49-2-03.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4341/files/Shinshu_Med49-2-03.pdf"}, "version_id": "540f2898-c826-4723-a319-67713fab2e5f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "thymidine phosphorylase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "node-negative", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "breast cancer", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "medroxyprogesterone", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "doxifluridine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "チミジンホスホリラーゼ", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "リンパ節陰性", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "乳癌", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "メドロキシプロゲステロン", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ドキシフルリジン", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討", "subitem_title_language": "ja"}, {"subitem_title": "Clinicopathological Significance of Thymidine Phosphorylase Expressed in Node-Negative Breast Cancer Tumors", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["549"], "permalink_uri": "http://hdl.handle.net/10091/9294", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-03-24"}, "publish_date": "2010-03-24", "publish_status": "0", "recid": "4341", "relation": {}, "relation_version_is_last": true, "title": ["リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討"], "weko_shared_id": -1}