{"created":"2021-03-01T06:08:10.425401+00:00","id":4341,"links":{},"metadata":{"_buckets":{"deposit":"809d96a2-d32a-47e6-8a09-43db42b779a5"},"_deposit":{"id":"4341","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4341"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00004341","sets":["461:463:464:549"]},"author_link":["10159","10160","10161","10162","10163","10164","10165","10166"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"83","bibliographicPageStart":"79","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"信州医学雑誌"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The expression of thymidine phosphorylase (dThd Pase) in node-negative human invasive ductal carcinoma tissues was investigated by the immunocytochemical method using anti-thymidine phosphorylase monoclonal antibody.Subjects were 5 recurrent and 30 non-recurrent patients who underwent surgery at the Department of Surgery at Shinshu University Hospital between 1993 and 1996.The median follow-up period was 62.5 months.Positive dThd Pase staining was observed in the five recurrent and four non-recurrent cases. Tumor recurrence was significantly more developed in patients with dThd Pase positive staining than in those with negative staining (p＜0.01).Among the nine dThd Pase positive cases,four patients who were administered doxifluridine (5’-DFUR) or medroxyprogesterone (MPA) did not manifest recurrence. Among the recurrent patients, two were cured by oral administration of 5’-DFUR or MPA. It is suggested that the expression of thymidine phosphorylase in human breast cancer tissues may be a risk factor for tumor recurrence. The prognosis of node-negative and dThd Pase positive breast cancer patients might be improved by hormonal therapy or oral administration of 5’-DFUR.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"信州医学雑誌 49(2): 79-83(2001)","subitem_description_type":"Other"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州医学会"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0037-3826","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00120815","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本原,  昭子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"麻沼,  和彦","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤森,  実","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土屋,  眞一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浜,  善久","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"丸山,  正幸","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"草間,  律","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"天野,  純","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Shinshu_Med49-2-03.pdf","filesize":[{"value":"314.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shinshu_Med49-2-03.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/4341/files/Shinshu_Med49-2-03.pdf"},"version_id":"540f2898-c826-4723-a319-67713fab2e5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"thymidine phosphorylase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"node-negative","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"breast cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"medroxyprogesterone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"doxifluridine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"チミジンホスホリラーゼ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ節陰性","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"乳癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"メドロキシプロゲステロン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ドキシフルリジン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討","subitem_title_language":"ja"},{"subitem_title":"Clinicopathological Significance of Thymidine Phosphorylase Expressed in Node-Negative Breast Cancer Tumors","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["549"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-24"},"publish_date":"2010-03-24","publish_status":"0","recid":"4341","relation_version_is_last":true,"title":["リンパ節転移陰性乳癌組織におけるthymidine phosphorylase発現症例の検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-02-24T00:55:41.529564+00:00"}