{"created":"2021-03-01T06:08:12.314393+00:00","id":4373,"links":{},"metadata":{"_buckets":{"deposit":"50ba4c9d-0eea-4743-b6c4-c5b5101957a2"},"_deposit":{"id":"4373","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4373"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00004373","sets":["461:463:464:558"]},"author_link":["10352","10353","10354","10355"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-10-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"391","bibliographicPageStart":"389","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"信州医学雑誌"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Myocarditis is a potentially lethal inflammatory disease in humans.In this disease,large amounts of cytokines are released from inflammatory cells,which then stimulate endothelial cells to secrete endothelin-1 (ET-1). ET-1 has been isolated from endothelial cells and is a key mediator in several cardiovascular diseases. However, the immunological effects of ET-1 in myocarditis have not been reported.To investigate the roles of ET-1 expression in myocarditis, immunohistochemistry and reverse transcription-polymerase chain eaction (RT-PCR)were used to detect ET-1 in rat hearts with experimental autoimmune myocarditis (EAM). The EAM rat hearts were harvested at days 7,14,21 and 28 (n＝12).For the control study,hearts from rats without immunization were also harvested at day 28 (n＝5). Immunohistochemically, ET-1 was faintly expressed in unimmunized hearts.In EAM hearts,ET-1 expression was enhanced in the endothelial cells of small vasculatures in the myocardium at days 7 and 14.ET-1 was observed prior to interstitial cell infiltration and myocardial damage. However, ET-1 expression was decreased in the myocardium at days 21 and 28. Using RT-PCR,a single band corresponding to ET-1 was detected in unimmunized and EAM samples on days 7 to 28.In this study,ET-1 was enhanced in the early phase of EAM,and decreased in the chronic phase.ET-1 may therefore play a critical role in the early stage of EAM inflammation and may have diagnostic value in clinical myocarditis.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"信州医学雑誌 47(5): 389-391(1999)","subitem_description_type":"Other"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州医学会"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0037-3826","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00120815","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"矢嶋,  紀幸","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木,  淳一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北林,  浩","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"磯部,  光章","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Shinshu_Med47-5-04.pdf","filesize":[{"value":"361.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shinshu_Med47-5-04.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/4373/files/Shinshu_Med47-5-04.pdf"},"version_id":"8f736028-38b6-4a68-bce3-9c7798d8a3cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"myocarditis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"エンドセリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現","subitem_title_language":"ja"},{"subitem_title":"Expression of Endothelin-1 in the Inflamed Myocardium of an Experimental Autoimmune Myocarditis Rat Model","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["558"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-24"},"publish_date":"2010-03-24","publish_status":"0","recid":"4373","relation_version_is_last":true,"title":["ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-02-24T00:51:39.404701+00:00"}