{"created":"2021-03-01T06:08:12.492484+00:00","id":4376,"links":{},"metadata":{"_buckets":{"deposit":"e7375894-c9ad-45c4-b893-e4cba1a378e4"},"_deposit":{"id":"4376","owners":[],"pid":{"revision_id":0,"type":"depid","value":"4376"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00004376","sets":["461:463:464:558"]},"author_link":["10365","10366","10367","10368","10369"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-10-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"404","bibliographicPageStart":"401","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"信州医学雑誌"}]}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Monocyte chemoattractant protein (MCP)-1is known to be critical in activating T lymphocytes,mast cells,and other cells.Recent studies show that MCP-1plays pivotal roles in several inflammatory conditions including the acute phase of cardiac allograft rejection.However,the pathophysiological roles of MCP-1in the neointimal formation of chronically rejected heart grafts remain unclear.To clarify the roles of MCP-1 in such allografts, we performed immunohistochemistry to detect MCP-1 and vascular cell adhesion molecule (VCAM)-1 using a murine cardiac allograft transplantation model (DBA/2 hearts to B10. D2 recipient mice). Transplanted cardiac allografts were harvested at days 14 (n＝5) and 60 (n＝5). For the control study,isografts were used (n＝5). Allografts harvested at day 14 demonstrated no arterial intimal thickening, while severe intimal thickening was observed in allografts harvested at day 60. MCP-1 and VCAM-1were observed in the vascular endothelium of rejected cardiac allografts at days14and 60,but were not observed in isografts. The expression of MCP-1 in the arteries was enhanced at day 14, but was decreased at day60.However,VCAM-1expression was increased at day60.These results indicate that the expression of MCP-1was enhanced prior to the development of intimal thickening and VCAM-1expression. MCP-1 may play pivotal roles in neointimal formation in the early phase of chronic rejection in cardiac allografts.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"信州医学雑誌 47(5): 401-404(1999)","subitem_description_type":"Other"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州医学会"}]},"item_6_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0037-3826","subitem_source_identifier_type":"PISSN"}]},"item_6_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00120815","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"町田,  水穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木,  淳一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋,  済","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"天野,  純","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"磯部,  光章","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-24"}],"displaytype":"detail","filename":"Shinshu_Med47-5-07.pdf","filesize":[{"value":"339.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shinshu_Med47-5-07.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/4376/files/Shinshu_Med47-5-07.pdf"},"version_id":"f5b9a561-fabf-4c49-82c9-0fb505bec302"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"heart transplantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic rejection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"coronary neointimal formation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"monocyte chemoattractant protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"心臓移植","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性拒絶","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"冠動脈肥厚内膜形成","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"単球遊走因子","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マウス移植心冠動脈における単球遊走因子の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス移植心冠動脈における単球遊走因子の発現","subitem_title_language":"ja"},{"subitem_title":"Expression of Monocyte Chemoattractant Protein-1 in Coronary Arteries of Murine Cardiac Allografts","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["558"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-24"},"publish_date":"2010-03-24","publish_status":"0","recid":"4376","relation_version_is_last":true,"title":["マウス移植心冠動脈における単球遊走因子の発現"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-02-24T00:46:52.905891+00:00"}