{"created":"2021-03-01T06:10:44.932286+00:00","id":6903,"links":{},"metadata":{"_buckets":{"deposit":"c97c6a3b-712c-4edc-bf5a-a10a63fa2322"},"_deposit":{"id":"6903","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6903"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00006903","sets":["461:463:805:811"]},"author_link":["16703","16704","16705","16706","16707","16708"],"item_10_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-02-28","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"119","bibliographicPageStart":"113","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"紀要"}]}]},"item_10_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Graves' disease is a common organ specific disorder characterized by immune response toward a number of thyroid proteins including thyroglobulin (Tg) , thyroid peroxidase (TPO) , and TSH receptor. Although considerable progress has been made in understanding and mapping the response of autoantibodies to Tg, much less is known about recognition of Tg by pathogenic T-cell in human diseases. To identify such reactions, we analyzed the proliferative responses of T-cells in the peripheral blood (PBMC) to Tg and to synthetic peptides. Nineteen patients with Graves' disease, 2 patients with chronic thyroiditis , and　5 normal subjects were studied. PBMC from 4 of the patients with Graves' disease reacted to Tg. Their reactivities to synthetic peptides were less than that to Tg. This may lead to a design of more accurate and specific diagnostic assays for the cellular immunity to the thyroid antigens in autoimmune thyroid disorders as well as to the development of specific immunotherapy for the disorders.","subitem_description_type":"Abstract"}]},"item_10_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"紀要 22: 113-119(1997)","subitem_description_type":"Other"}]},"item_10_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"信州大学医療技術短期大学部"}]},"item_10_source_id_35":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-1982","subitem_source_identifier_type":"ISSN"}]},"item_10_source_id_40":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10402438","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤,  亮二","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥山,  英理子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"亀子,  文子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"春日,  好雄","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉沢,  要","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"降旗,  謙一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"Allied_Med22_12.pdf","filesize":[{"value":"428.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Allied_Med22_12.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/6903/files/Allied_Med22_12.pdf"},"version_id":"5ae20f0a-944f-4c1e-bb0e-e0c148847640"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"T-cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thyroglobulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Synthetic peptides","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"増殖","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サイログロブリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"合成ペプチド","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"サイログロブリンおよびその合成ペプチド抗原に対するバセドウ病患者T細胞の反応性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サイログロブリンおよびその合成ペプチド抗原に対するバセドウ病患者T細胞の反応性","subitem_title_language":"ja"},{"subitem_title":"Reactivity of the T-Cells in Graves'disease to human thyroglobulin and synthetic peptides","subitem_title_language":"en"}]},"item_type_id":"10","owner":"1","path":["811"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-03-01"},"publish_date":"2010-03-01","publish_status":"0","recid":"6903","relation_version_is_last":true,"title":["サイログロブリンおよびその合成ペプチド抗原に対するバセドウ病患者T細胞の反応性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-02-13T01:07:31.491394+00:00"}