{"created":"2021-03-01T06:11:01.371694+00:00","id":7174,"links":{},"metadata":{"_buckets":{"deposit":"20c74238-8cf6-48eb-8e04-f1da24879926"},"_deposit":{"id":"7174","owners":[],"pid":{"revision_id":0,"type":"depid","value":"7174"},"status":"published"},"_oai":{"id":"oai:soar-ir.repo.nii.ac.jp:00007174","sets":["461:848:849"]},"author_link":["17277","17278","17279","17280","17281","17282","17283","17284","17285","17286","17287"],"item_1628147817048":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"406","bibliographicPageStart":"401","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF PSYCHIATRIC RESEARCH"}]}]},"item_6_description_19":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"信州大学博士（医学）・学位論文・平成25年3月31日授与（甲第944号）・篠山 大明","subitem_description_type":"Other"}]},"item_6_description_20":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Elevated peripheral levels of interleukin-6 (IL-6) are common findings in schizophrenia and depression. However, previous studies that measured cerebrospinal fluid (CSF) IL-6 levels in these disorders reported controversial results. The present study examined whether CSF IL-6 levels are altered in patients with schizophrenia and those with depression. Lumbar punctures were performed in 32 patients with schizophrenia, 30 with major depressive disorder (MDD), and 35 healthy controls. Serum samples were simultaneously collected from all subjects in the patient groups and from 32 of the control group. CSF and serum IL-6 levels were determined by enzyme-linked immunosorbent assay. Both the patients with schizophrenia and MDD had significantly higher CSF IL-6 levels compared to the controls (schizophrenia: P = 0.0027; MDD: P = 0.012). IL-6 levels were significantly higher in the CSF than in the serum. No significant correlation was observed between CSF and serum IL-6 levels. The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded. (C) 2012 Elsevier Ltd. All rights reserved.","subitem_description_type":"Abstract"}]},"item_6_description_30":{"attribute_name":"資源タイプ（コンテンツの種類）","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_6_description_5":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"JOURNAL OF PSYCHIATRIC RESEARCH. 47(3):401-406 (2013)","subitem_description_type":"Other"}]},"item_6_publisher_4":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PERGAMON-ELSEVIER SCIENCE LTD"}]},"item_6_relation_48":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.jpsychires.2012.12.001"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jpsychires.2012.12.001","subitem_relation_type_select":"DOI"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasayama,  Daimei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori,  Kotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakabayashi,  Chisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Teraishi,  Toshiya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori,  Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota,  Miho"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida,  Sumiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arima,  Kunimasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Higuchi,  Teruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amano,  Naoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kunugi,  Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-09-25"}],"displaytype":"detail","filename":"H24Kou944_Sasayama.pdf","filesize":[{"value":"360.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"H24Kou944_Sasayama.pdf","url":"https://soar-ir.repo.nii.ac.jp/record/7174/files/H24Kou944_Sasayama.pdf"},"version_id":"67859512-9793-4c44-93e3-79e629e94a06"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["849"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-06-27"},"publish_date":"2014-06-27","publish_status":"0","recid":"7174","relation_version_is_last":true,"title":["Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2022-12-14T03:54:10.869208+00:00"}